TY - JOUR
T1 - The C3b/C4b receptor (CR1, CD35) on erythrocytes
T2 - Methods for study of the polymorphisms
AU - Cohen, Jacques H.M.
AU - Atkinson, John P.
AU - Klickstein, Lloyd B.
AU - Oudin, Stephane
AU - Subramanian, V. Bala
AU - Moulds, Joann M.
PY - 1999/9
Y1 - 1999/9
N2 - This report is devoted to methodologies used in analyzing the C3b/C4b receptor (CR1, CD35) on erythrocytes (E), its soluble form, the CR1 structural or allotype polymorphism, and CR1 density polymorphism. In primates E CR1 serves as the main system for processing and clearance of complement opsonized immune complexes (IC). CR1 copy numbers decrease with aging of E in normal individuals. Erythrocyte CR1 is also decreased in pathological conditions such as systemic lupus erythematosus (SLE), HIV infection, certain hemolytic anemias, and many other conditions featuring immune complexes. Consequently, CRI on E has an important physiological role in immune complex handling and has interesting alterations in disease. (C) 1999 Elsevier Science Ltd.
AB - This report is devoted to methodologies used in analyzing the C3b/C4b receptor (CR1, CD35) on erythrocytes (E), its soluble form, the CR1 structural or allotype polymorphism, and CR1 density polymorphism. In primates E CR1 serves as the main system for processing and clearance of complement opsonized immune complexes (IC). CR1 copy numbers decrease with aging of E in normal individuals. Erythrocyte CR1 is also decreased in pathological conditions such as systemic lupus erythematosus (SLE), HIV infection, certain hemolytic anemias, and many other conditions featuring immune complexes. Consequently, CRI on E has an important physiological role in immune complex handling and has interesting alterations in disease. (C) 1999 Elsevier Science Ltd.
KW - Complement
KW - Complement 3b
KW - Erythrocytes
KW - Laboratory techniques and procedures
KW - Receptors
UR - http://www.scopus.com/inward/record.url?scp=0033379070&partnerID=8YFLogxK
U2 - 10.1016/S0161-5890(99)00102-9
DO - 10.1016/S0161-5890(99)00102-9
M3 - Article
C2 - 10698335
AN - SCOPUS:0033379070
SN - 0161-5890
VL - 36
SP - 819
EP - 825
JO - Molecular Immunology
JF - Molecular Immunology
IS - 13-14
ER -