The C-terminal ester of membrane anchored peptide ion channels affects anion transport

Natasha Djedovic; Riccardo Ferdani; Egan Harder; Jolanta Pajewska; Robert Pajewski; Paul H. Schlesinger; George W. Gokel

doi:10.1039/b312209n

The C-terminal ester of membrane anchored peptide ion channels affects anion transport

Natasha Djedovic, Riccardo Ferdani, Egan Harder, Jolanta Pajewska, Robert Pajewski, Paul H. Schlesinger, George W. Gokel

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Five heptapeptide derivatives, [CH₃(CH₂)₁₇]₂NCOCH₂OCH₂CO-Gly-Gly-Gly-Pro-Gly-Gly-Gly-OR, in which R = ethyl, 2-propyl, heptyl, benzyl, and cyclohexylmethyl, were found to transport chloride anion through a phospholipid bilayer to varying extents dependent on the identity of R. It was concluded that the R group is a membrane anchor for the synthetic chloride channels.

Original language	English
Pages (from-to)	2862-2863
Number of pages	2
Journal	Chemical Communications
Volume	3
Issue number	23
DOIs	https://doi.org/10.1039/b312209n
State	Published - 2003

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title = "The C-terminal ester of membrane anchored peptide ion channels affects anion transport",

abstract = "Five heptapeptide derivatives, [CH3(CH2)17]2NCOCH2OCH2CO-Gly-Gly-Gly-Pro-Gly-Gly-Gly-OR, in which R = ethyl, 2-propyl, heptyl, benzyl, and cyclohexylmethyl, were found to transport chloride anion through a phospholipid bilayer to varying extents dependent on the identity of R. It was concluded that the R group is a membrane anchor for the synthetic chloride channels.",

author = "Natasha Djedovic and Riccardo Ferdani and Egan Harder and Jolanta Pajewska and Robert Pajewski and Schlesinger, {Paul H.} and Gokel, {George W.}",

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journal = "Chemical Communications",

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T1 - The C-terminal ester of membrane anchored peptide ion channels affects anion transport

AU - Djedovic, Natasha

AU - Ferdani, Riccardo

AU - Harder, Egan

AU - Pajewska, Jolanta

AU - Pajewski, Robert

AU - Schlesinger, Paul H.

AU - Gokel, George W.

PY - 2003

Y1 - 2003

N2 - Five heptapeptide derivatives, [CH3(CH2)17]2NCOCH2OCH2CO-Gly-Gly-Gly-Pro-Gly-Gly-Gly-OR, in which R = ethyl, 2-propyl, heptyl, benzyl, and cyclohexylmethyl, were found to transport chloride anion through a phospholipid bilayer to varying extents dependent on the identity of R. It was concluded that the R group is a membrane anchor for the synthetic chloride channels.

AB - Five heptapeptide derivatives, [CH3(CH2)17]2NCOCH2OCH2CO-Gly-Gly-Gly-Pro-Gly-Gly-Gly-OR, in which R = ethyl, 2-propyl, heptyl, benzyl, and cyclohexylmethyl, were found to transport chloride anion through a phospholipid bilayer to varying extents dependent on the identity of R. It was concluded that the R group is a membrane anchor for the synthetic chloride channels.

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U2 - 10.1039/b312209n

DO - 10.1039/b312209n

M3 - Article

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AN - SCOPUS:0344442304

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VL - 3

SP - 2862

EP - 2863

JO - Chemical Communications

JF - Chemical Communications

IS - 23

ER -

The C-terminal ester of membrane anchored peptide ion channels affects anion transport

Abstract

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