The C-terminal ester of membrane anchored peptide ion channels affects anion transport

Natasha Djedovic, Riccardo Ferdani, Egan Harder, Jolanta Pajewska, Robert Pajewski, Paul H. Schlesinger, George W. Gokel

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Five heptapeptide derivatives, [CH3(CH2)17]2NCOCH2OCH2CO-Gly-Gly-Gly-Pro-Gly-Gly-Gly-OR, in which R = ethyl, 2-propyl, heptyl, benzyl, and cyclohexylmethyl, were found to transport chloride anion through a phospholipid bilayer to varying extents dependent on the identity of R. It was concluded that the R group is a membrane anchor for the synthetic chloride channels.

Original languageEnglish
Pages (from-to)2862-2863
Number of pages2
JournalChemical Communications
Volume3
Issue number23
DOIs
StatePublished - 2003

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