TY - JOUR
T1 - The broad-spectrum antiviral functions of IFIT and IFITM proteins
AU - Diamond, Michael S.
AU - Farzan, Michael
N1 - Funding Information:
The authors would like to thank M. Gale, G. Sen and members of their laboratories for helpful discussions. We also greatly appreciate the critical comments made by J. Hyde, J. White, M. Gack and T. Pierson on the manuscript, and the help with figure preparation from J. Brien and S. K. Austin. This work was supported by US National Institutes of Health grants U54 AI081680 (Pacific Northwest Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research (to M.S.D.)), U54 AI057159 (New England Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research (to M.F.)) and U19 AI083019 (to M.S.D.).
PY - 2013/1
Y1 - 2013/1
N2 - Over the past few years, several groups have identified new genes that are transcriptionally induced downstream of type I interferon (IFN) signalling and that inhibit infection by individual or multiple families of viruses. Among these IFN-stimulated genes with antiviral activity are two genetically and functionally distinct families-the IFN-induced protein with tetratricopeptide repeats (IFIT) family and the IFN-induced transmembrane protein (IFITM) family. This Review focuses on recent advances in identifying the unique mechanisms of action of IFIT and IFITM proteins, which explain their broad-spectrum activity against the replication, spread and pathogenesis of a range of human viruses.
AB - Over the past few years, several groups have identified new genes that are transcriptionally induced downstream of type I interferon (IFN) signalling and that inhibit infection by individual or multiple families of viruses. Among these IFN-stimulated genes with antiviral activity are two genetically and functionally distinct families-the IFN-induced protein with tetratricopeptide repeats (IFIT) family and the IFN-induced transmembrane protein (IFITM) family. This Review focuses on recent advances in identifying the unique mechanisms of action of IFIT and IFITM proteins, which explain their broad-spectrum activity against the replication, spread and pathogenesis of a range of human viruses.
UR - http://www.scopus.com/inward/record.url?scp=84871484827&partnerID=8YFLogxK
U2 - 10.1038/nri3344
DO - 10.1038/nri3344
M3 - Review article
C2 - 23237964
AN - SCOPUS:84871484827
SN - 1474-1733
VL - 13
SP - 46
EP - 57
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 1
ER -