The broad-spectrum antiviral functions of IFIT and IFITM proteins

Michael S. Diamond, Michael Farzan

Research output: Contribution to journalReview articlepeer-review

373 Scopus citations

Abstract

Over the past few years, several groups have identified new genes that are transcriptionally induced downstream of type I interferon (IFN) signalling and that inhibit infection by individual or multiple families of viruses. Among these IFN-stimulated genes with antiviral activity are two genetically and functionally distinct families-the IFN-induced protein with tetratricopeptide repeats (IFIT) family and the IFN-induced transmembrane protein (IFITM) family. This Review focuses on recent advances in identifying the unique mechanisms of action of IFIT and IFITM proteins, which explain their broad-spectrum activity against the replication, spread and pathogenesis of a range of human viruses.

Original languageEnglish
Pages (from-to)46-57
Number of pages12
JournalNature Reviews Immunology
Volume13
Issue number1
DOIs
StatePublished - Jan 2013

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