Over the past few years, several groups have identified new genes that are transcriptionally induced downstream of type I interferon (IFN) signalling and that inhibit infection by individual or multiple families of viruses. Among these IFN-stimulated genes with antiviral activity are two genetically and functionally distinct families-the IFN-induced protein with tetratricopeptide repeats (IFIT) family and the IFN-induced transmembrane protein (IFITM) family. This Review focuses on recent advances in identifying the unique mechanisms of action of IFIT and IFITM proteins, which explain their broad-spectrum activity against the replication, spread and pathogenesis of a range of human viruses.

Original languageEnglish
Pages (from-to)46-57
Number of pages12
JournalNature Reviews Immunology
Issue number1
StatePublished - Jan 2013


Dive into the research topics of 'The broad-spectrum antiviral functions of IFIT and IFITM proteins'. Together they form a unique fingerprint.

Cite this