The brain’s regulators: CNS immune patrol

Gustavo Gastão Davanzo; Jonathan Kipnis

doi:10.1038/s41590-025-02116-8

The brain’s regulators: CNS immune patrol

Gustavo Gastão Davanzo
, Jonathan Kipnis

Research output: Contribution to journal › Article › peer-review

Abstract

Once seen as a passive barrier, the dura mater is now recognized as an active immune site. A study now suggests that regulatory T cells within the dura mater modulate immune responses by restricting the production of IFNγ and controlling immune cell infiltration in the central nervous system (CNS) parenchyma.

Original language	English
Article number	7967
Pages (from-to)	534-535
Number of pages	2
Journal	Nature immunology
Volume	26
Issue number	4
DOIs	https://doi.org/10.1038/s41590-025-02116-8
State	Published - Apr 2025

Access to Document

10.1038/s41590-025-02116-8

Cite this

@article{f1338f413acd4cccb6226113baf6897b,

title = "The brain{\textquoteright}s regulators: CNS immune patrol",

abstract = "Once seen as a passive barrier, the dura mater is now recognized as an active immune site. A study now suggests that regulatory T cells within the dura mater modulate immune responses by restricting the production of IFNγ and controlling immune cell infiltration in the central nervous system (CNS) parenchyma.",

author = "Davanzo, \{Gustavo Gast{\~a}o\} and Jonathan Kipnis",

note = "Publisher Copyright: {\textcopyright} Springer Nature America, Inc. 2025.",

year = "2025",

month = apr,

doi = "10.1038/s41590-025-02116-8",

language = "English",

volume = "26",

pages = "534--535",

journal = "Nature immunology",

issn = "1529-2908",

number = "4",

}

TY - JOUR

T1 - The brain’s regulators

T2 - CNS immune patrol

AU - Davanzo, Gustavo Gastão

AU - Kipnis, Jonathan

N1 - Publisher Copyright: © Springer Nature America, Inc. 2025.

PY - 2025/4

Y1 - 2025/4

N2 - Once seen as a passive barrier, the dura mater is now recognized as an active immune site. A study now suggests that regulatory T cells within the dura mater modulate immune responses by restricting the production of IFNγ and controlling immune cell infiltration in the central nervous system (CNS) parenchyma.

AB - Once seen as a passive barrier, the dura mater is now recognized as an active immune site. A study now suggests that regulatory T cells within the dura mater modulate immune responses by restricting the production of IFNγ and controlling immune cell infiltration in the central nervous system (CNS) parenchyma.

UR - https://www.scopus.com/pages/publications/105000832100

U2 - 10.1038/s41590-025-02116-8

DO - 10.1038/s41590-025-02116-8

M3 - Article

C2 - 40108421

AN - SCOPUS:105000832100

SN - 1529-2908

VL - 26

SP - 534

EP - 535

JO - Nature immunology

JF - Nature immunology

IS - 4

M1 - 7967

ER -

The brain’s regulators: CNS immune patrol

Abstract

Access to Document

Other files and links

Fingerprint

Cite this