The brain, sirtuins, and ageing

Akiko Satoh, Shin Ichiro Imai, Leonard Guarente

Research output: Contribution to journalReview articlepeer-review

89 Scopus citations

Abstract

In mammals, recent studies have demonstrated that the brain, the hypothalamus in particular, is a key bidirectional integrator of humoral and neural information from peripheral tissues, thus influencing ageing both in the brain and at the 'systemic' level. CNS decline drives the progressive impairment of cognitive, social and physical abilities, and the mechanisms underlying CNS regulation of the ageing process, such as microglia-neuron networks and the activities of sirtuins, a class of NAD + -dependent deacylases, are beginning to be understood. Such mechanisms are potential targets for the prevention or treatment of age-associated dysfunction and for the extension of a healthy lifespan.

Original languageEnglish
Pages (from-to)362-374
Number of pages13
JournalNature Reviews Neuroscience
Volume18
Issue number6
DOIs
StatePublished - Jun 1 2017

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