TY - JOUR
T1 - The brain as a structure
T2 - A model of how fluid–structure interactions stiffen brain tissue after injury
AU - Feng, Yuan
AU - Chen, Yu
AU - Yao, Yifei
AU - Li, Xiaowei
AU - Zhang, Aili
AU - Genin, Guy M.
N1 - Funding Information:
Funding support was provided by grant 31870941 from National Natural Science Foundation of China (NSFC), and grant 19441907700 from Shanghai Science and Technology Committee (STCSM).
Funding Information:
This paper is dedicated to our friend and mentor, Prof. Phillip L. Gould. Phil's impact on both the field and us cannot be overstated. YF and GMG both met him at Washington University, YF as a graduate student and GMG as an assistant professor. In addition to us, Phil's rich knowledge, scholarship, and care have inspired many students and mentees. YF's first course at Washington University was Phil's linear elasticity, and he loved it so much that he stayed on as a teaching assistant and continued to stay on as co-author of the fourth edition of the textbook, ?Introduction to Linear Elasticity;? this launched YF into a much-enjoyed foray into biomechanics research at Washington University, and laid the foundation for his current interdisciplinary research with MR imaging. Phil, you are a highly respected researcher, a deeply loved mentor, and a dear friend. We are delighted to write this paper as a tribute to you. Funding support was provided by grant 31870941 from National Natural Science Foundation of China (NSFC), and grant 19441907700 from Shanghai Science and Technology Committee (STCSM).
Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/4/1
Y1 - 2022/4/1
N2 - The brain contains a tree of vasculature that contributes not only oxygen and nutrients but also structural integrity to the brain parenchyma. The structure formed by this vasculature affects the mechanical response of brain tissue both before and after injury, and maybe a determinant of an individual's injury susceptibility. To investigate structural changes of brain tissue after injury, we constructed an idealized representative volume element model of fluid–structure interactions within brain parenchyma and applied it to study how vessel size, cerebral spinal fluid (CSF) flow velocity, and CSF flow networks relate to previous experimental observations of healthy and injured brain tissue. We hypothesized that injury-associated structural changes to the neurovasculature may alter the mechanical responses of brain tissue and predispose an individual to subsequent injury. Parameters representing the mechanics of uninjured and injured brain tissue were verified against experimental characterizations of these tissue in uniaxial compression and shear. Results supported our hypothesis, and highlight the importance of considering cerebral vasculature as a structure in predicting and analyzing the brain's response to mechanical loading.
AB - The brain contains a tree of vasculature that contributes not only oxygen and nutrients but also structural integrity to the brain parenchyma. The structure formed by this vasculature affects the mechanical response of brain tissue both before and after injury, and maybe a determinant of an individual's injury susceptibility. To investigate structural changes of brain tissue after injury, we constructed an idealized representative volume element model of fluid–structure interactions within brain parenchyma and applied it to study how vessel size, cerebral spinal fluid (CSF) flow velocity, and CSF flow networks relate to previous experimental observations of healthy and injured brain tissue. We hypothesized that injury-associated structural changes to the neurovasculature may alter the mechanical responses of brain tissue and predispose an individual to subsequent injury. Parameters representing the mechanics of uninjured and injured brain tissue were verified against experimental characterizations of these tissue in uniaxial compression and shear. Results supported our hypothesis, and highlight the importance of considering cerebral vasculature as a structure in predicting and analyzing the brain's response to mechanical loading.
KW - Brain injury
KW - Fluid–structure interactions
KW - Tissue mechanics
UR - http://www.scopus.com/inward/record.url?scp=85123980736&partnerID=8YFLogxK
U2 - 10.1016/j.engstruct.2022.113960
DO - 10.1016/j.engstruct.2022.113960
M3 - Article
AN - SCOPUS:85123980736
SN - 0141-0296
VL - 256
JO - Engineering Structures
JF - Engineering Structures
M1 - 113960
ER -