The bone marrow Niche in Waldenström's macroglobulinemia

Irene M. Ghobrial, Yong Zhang, Yang Liu, Hai Ngo, Feda Azab, Antonio Sacco, Abdelkareem Azab, Patricia Maiso, Brittany Morgan, Phong Quang, Ghayas Issa, Aldo Roccaro

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The widespread involvement of the bone marrow with tumor cells indicates that there is continuous cell trafficking of WM cells in and out of the bone marrow leading to cell dissemination in the bone marrow and in the lymph nodes in many patients with WM. The interaction of the WM cells with the bone marrow is critical for the regulation of cell proliferation, cell cycle, drug resistance as well as cell dissemination and trafficking. Advances in understanding the interaction of the tumor clone with the BM microenvironment have led to the development of therapeutic agents that not only target the tumor clone but also regulate the bone marrow microenvironment. Here, we review the role of the cellular and liquid bone marrow compartments in the regulation of cell proliferation and dissemination in WM.

Original languageEnglish
Pages (from-to)118-120
Number of pages3
JournalClinical Lymphoma, Myeloma and Leukemia
Issue number1
StatePublished - Feb 1 2011


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