The bone marrow Niche in Waldenström's macroglobulinemia

Irene M. Ghobrial; Yong Zhang; Yang Liu; Hai Ngo; Feda Azab; Antonio Sacco; Abdelkareem Azab; Patricia Maiso; Brittany Morgan; Phong Quang; Ghayas Issa; Aldo Roccaro

doi:10.3816/CLML.2011.n.025

The bone marrow Niche in Waldenström's macroglobulinemia

Irene M. Ghobrial, Yong Zhang, Yang Liu, Hai Ngo, Feda Azab, Antonio Sacco, Abdelkareem Azab, Patricia Maiso, Brittany Morgan, Phong Quang, Ghayas Issa, Aldo Roccaro

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Abstract

The widespread involvement of the bone marrow with tumor cells indicates that there is continuous cell trafficking of WM cells in and out of the bone marrow leading to cell dissemination in the bone marrow and in the lymph nodes in many patients with WM. The interaction of the WM cells with the bone marrow is critical for the regulation of cell proliferation, cell cycle, drug resistance as well as cell dissemination and trafficking. Advances in understanding the interaction of the tumor clone with the BM microenvironment have led to the development of therapeutic agents that not only target the tumor clone but also regulate the bone marrow microenvironment. Here, we review the role of the cellular and liquid bone marrow compartments in the regulation of cell proliferation and dissemination in WM.

Original language	English
Pages (from-to)	118-120
Number of pages	3
Journal	Clinical Lymphoma, Myeloma and Leukemia
Volume	11
Issue number	1
DOIs	https://doi.org/10.3816/CLML.2011.n.025
State	Published - Feb 1 2011

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title = "The bone marrow Niche in Waldenstr{\"o}m's macroglobulinemia",

abstract = "The widespread involvement of the bone marrow with tumor cells indicates that there is continuous cell trafficking of WM cells in and out of the bone marrow leading to cell dissemination in the bone marrow and in the lymph nodes in many patients with WM. The interaction of the WM cells with the bone marrow is critical for the regulation of cell proliferation, cell cycle, drug resistance as well as cell dissemination and trafficking. Advances in understanding the interaction of the tumor clone with the BM microenvironment have led to the development of therapeutic agents that not only target the tumor clone but also regulate the bone marrow microenvironment. Here, we review the role of the cellular and liquid bone marrow compartments in the regulation of cell proliferation and dissemination in WM.",

author = "Ghobrial, {Irene M.} and Yong Zhang and Yang Liu and Hai Ngo and Feda Azab and Antonio Sacco and Abdelkareem Azab and Patricia Maiso and Brittany Morgan and Phong Quang and Ghayas Issa and Aldo Roccaro",

note = "Funding Information: Supported in part by the International Waldenstrom Macroglobulinemia Foundation (IWMF), Kirsch Lab for Waldenstrom and Heje Fellowship for WM.",

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T1 - The bone marrow Niche in Waldenström's macroglobulinemia

AU - Ghobrial, Irene M.

AU - Zhang, Yong

AU - Liu, Yang

AU - Ngo, Hai

AU - Azab, Feda

AU - Sacco, Antonio

AU - Azab, Abdelkareem

AU - Maiso, Patricia

AU - Morgan, Brittany

AU - Quang, Phong

AU - Issa, Ghayas

AU - Roccaro, Aldo

N1 - Funding Information: Supported in part by the International Waldenstrom Macroglobulinemia Foundation (IWMF), Kirsch Lab for Waldenstrom and Heje Fellowship for WM.

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N2 - The widespread involvement of the bone marrow with tumor cells indicates that there is continuous cell trafficking of WM cells in and out of the bone marrow leading to cell dissemination in the bone marrow and in the lymph nodes in many patients with WM. The interaction of the WM cells with the bone marrow is critical for the regulation of cell proliferation, cell cycle, drug resistance as well as cell dissemination and trafficking. Advances in understanding the interaction of the tumor clone with the BM microenvironment have led to the development of therapeutic agents that not only target the tumor clone but also regulate the bone marrow microenvironment. Here, we review the role of the cellular and liquid bone marrow compartments in the regulation of cell proliferation and dissemination in WM.

AB - The widespread involvement of the bone marrow with tumor cells indicates that there is continuous cell trafficking of WM cells in and out of the bone marrow leading to cell dissemination in the bone marrow and in the lymph nodes in many patients with WM. The interaction of the WM cells with the bone marrow is critical for the regulation of cell proliferation, cell cycle, drug resistance as well as cell dissemination and trafficking. Advances in understanding the interaction of the tumor clone with the BM microenvironment have led to the development of therapeutic agents that not only target the tumor clone but also regulate the bone marrow microenvironment. Here, we review the role of the cellular and liquid bone marrow compartments in the regulation of cell proliferation and dissemination in WM.

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The bone marrow Niche in Waldenström's macroglobulinemia

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