TY - JOUR
T1 - The biology of TREM receptors
AU - Colonna, Marco
N1 - Funding Information:
The author thanks S. Gilfillan, J. Klesney-Tait, M. Molgora, Y. Chen, M. B. Humphrey, D. McVicar and M. Cella for critical reading. This work is supported by the US National Institutes of Health (RF1 AG051485, R21 AG059176, R01 CA262684 and RF1 AG059082).
Publisher Copyright:
© 2023, Springer Nature Limited.
PY - 2023/9
Y1 - 2023/9
N2 - Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages. These receptors have been implicated in inflammation, neurodegenerative diseases, bone remodelling, metabolic syndrome, atherosclerosis and cancer. Here, I review the structure, ligands, signalling modes and functions of TREMs in humans and mice and discuss the challenges that remain in understanding TREM biology.
AB - Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages. These receptors have been implicated in inflammation, neurodegenerative diseases, bone remodelling, metabolic syndrome, atherosclerosis and cancer. Here, I review the structure, ligands, signalling modes and functions of TREMs in humans and mice and discuss the challenges that remain in understanding TREM biology.
UR - http://www.scopus.com/inward/record.url?scp=85147576706&partnerID=8YFLogxK
U2 - 10.1038/s41577-023-00837-1
DO - 10.1038/s41577-023-00837-1
M3 - Review article
C2 - 36750615
AN - SCOPUS:85147576706
SN - 1474-1733
VL - 23
SP - 580
EP - 594
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 9
ER -