The biology and management of non-small cell lung cancer

Roy S. Herbst, Daniel Morgensztern, Chris Boshoff

Research output: Contribution to journalReview article

435 Scopus citations

Abstract

Important advancements in the treatment of non-small cell lung cancer (NSCLC) have been achieved over the past two decades, increasing our understanding of the disease biology and mechanisms of tumour progression, and advancing early detection and multimodal care. The use of small molecule tyrosine kinase inhibitors and immunotherapy has led to unprecedented survival benefits in selected patients. However, the overall cure and survival rates for NSCLC remain low, particularly in metastatic disease. Therefore, continued research into new drugs and combination therapies is required to expand the clinical benefit to a broader patient population and to improve outcomes in NSCLC.

Original languageEnglish
Pages (from-to)446-454
Number of pages9
JournalNature
Volume553
Issue number7689
DOIs
StatePublished - Jan 24 2018

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