The biology and future prospects of antivirulence therapies

Lynette Cegelski, Garland R. Marshall, Gary R. Eldridge, Scott J. Hultgren

Research output: Contribution to journalReview articlepeer-review

547 Scopus citations


The emergence and increasing prevalence of bacterial strains that are resistant to available antibiotics demand the discovery of new therapeutic approaches. Targeting bacterial virulence is an alternative approach to antimicrobial therapy that offers promising opportunities to inhibit pathogenesis and its consequences without placing immediate life-or-death pressure on the target bacterium. Certain virulence factors have been shown to be potential targets for drug design and therapeutic intervention, whereas new insights are crucial for exploiting others. Targeting virulence represents a new paradigm to empower the clinician to prevent and treat infectious diseases.

Original languageEnglish
Pages (from-to)17-27
Number of pages11
JournalNature Reviews Microbiology
Issue number1
StatePublished - Jan 2008

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