TY - JOUR
T1 - The biodistribution of [153Gd]Gd-labeled magnetic resonance contrast agents in a transgenic mouse model of renal failure differs greatly from control mice
AU - Wadas, Thaddeus J.
AU - Sherman, Christopher D.
AU - Miner, Jeffrey H.
AU - Duncan, James R.
AU - Anderson, Carolyn J.
PY - 2010/11
Y1 - 2010/11
N2 - Nephrogenic systemic fibrosis occurs in renally impaired patients who have undergone contrast enhanced MR examination using intravenous gadolinium-based contrast agents. The effect of impaired kidney function on the biodistribution of gadolinium-based contrast agents was investigated using radiolabeled 153/Natgadolinium-DOTA, 153/Natgadolinium-DTPA, and 153/Natgadolinium-DTPA-BMA in a transgenic mouse model of renal impairment. Renally impaired animals had more activity associated with their tissues than did control mice, and this increase varied according to the radiotracer injected. For example, after 7 days, renally impaired animals that received 153/NatGd-DOTA had 3-fold (P < 0.037) more activity in their bone tissue, whereas renally impaired animals receiving 153/NatGd-DTPA and 153/NatGd-DTPA-BMA had 8-fold (P < 0.0001) and 24-fold (P < 0.0001) more activity in their bone tissue, respectively. These findings demonstrate that renal impairment dramatically alters the tissue distribution of Gd3+ ions in vivo, which are likely a critical factor in the development of nephrogenic systemic fibrosis.
AB - Nephrogenic systemic fibrosis occurs in renally impaired patients who have undergone contrast enhanced MR examination using intravenous gadolinium-based contrast agents. The effect of impaired kidney function on the biodistribution of gadolinium-based contrast agents was investigated using radiolabeled 153/Natgadolinium-DOTA, 153/Natgadolinium-DTPA, and 153/Natgadolinium-DTPA-BMA in a transgenic mouse model of renal impairment. Renally impaired animals had more activity associated with their tissues than did control mice, and this increase varied according to the radiotracer injected. For example, after 7 days, renally impaired animals that received 153/NatGd-DOTA had 3-fold (P < 0.037) more activity in their bone tissue, whereas renally impaired animals receiving 153/NatGd-DTPA and 153/NatGd-DTPA-BMA had 8-fold (P < 0.0001) and 24-fold (P < 0.0001) more activity in their bone tissue, respectively. These findings demonstrate that renal impairment dramatically alters the tissue distribution of Gd3+ ions in vivo, which are likely a critical factor in the development of nephrogenic systemic fibrosis.
KW - Alport syndrome
KW - Gadolinium
KW - Magnetic resonance imaging
KW - Nephrogenic systemic fibrosis
UR - http://www.scopus.com/inward/record.url?scp=78349253807&partnerID=8YFLogxK
U2 - 10.1002/mrm.22553
DO - 10.1002/mrm.22553
M3 - Article
C2 - 20648683
AN - SCOPUS:78349253807
SN - 0740-3194
VL - 64
SP - 1274
EP - 1280
JO - Magnetic resonance in medicine
JF - Magnetic resonance in medicine
IS - 5
ER -