The Bax pore in liposomes, Biophysics

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Abstract

The protein BAX of the Bcl-2-family is felt to be one of the two Bcl-2-family proteins that directly participate in the mitochondrial cytochrome c-translocating pore. We have studied the kinetics, stoichiometry and size of the pore formed by BAX in planar lipid bilayers and synthetic liposomes. Our data indicate that a cytochrome c-competent pore can be formed by in-membrane association of BAX monomers.

Original languageEnglish
Pages (from-to)1403-1408
Number of pages6
JournalCell Death and Differentiation
Volume13
Issue number8
DOIs
StatePublished - Aug 2006

Keywords

  • Apoptosis
  • Bax
  • Cytochrome c
  • Pore

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