The Bax pore in liposomes, Biophysics

Paul H. Schlesinger; M. Saito

doi:10.1038/sj.cdd.4401991

The Bax pore in liposomes, Biophysics

Paul H. Schlesinger, M. Saito

Research output: Contribution to journal › Review article › peer-review

30 Scopus citations

Abstract

The protein BAX of the Bcl-2-family is felt to be one of the two Bcl-2-family proteins that directly participate in the mitochondrial cytochrome c-translocating pore. We have studied the kinetics, stoichiometry and size of the pore formed by BAX in planar lipid bilayers and synthetic liposomes. Our data indicate that a cytochrome c-competent pore can be formed by in-membrane association of BAX monomers.

Original language	English
Pages (from-to)	1403-1408
Number of pages	6
Journal	Cell Death and Differentiation
Volume	13
Issue number	8
DOIs	https://doi.org/10.1038/sj.cdd.4401991
State	Published - Aug 2006

Keywords

Apoptosis
Bax
Cytochrome c
Pore

Access to Document

10.1038/sj.cdd.4401991

Cite this

@article{19c6cfdf12b04fdabae25c7dc8bedde9,

title = "The Bax pore in liposomes, Biophysics",

abstract = "The protein BAX of the Bcl-2-family is felt to be one of the two Bcl-2-family proteins that directly participate in the mitochondrial cytochrome c-translocating pore. We have studied the kinetics, stoichiometry and size of the pore formed by BAX in planar lipid bilayers and synthetic liposomes. Our data indicate that a cytochrome c-competent pore can be formed by in-membrane association of BAX monomers.",

keywords = "Apoptosis, Bax, Cytochrome c, Pore",

author = "Schlesinger, {Paul H.} and M. Saito",

year = "2006",

month = aug,

doi = "10.1038/sj.cdd.4401991",

language = "English",

volume = "13",

pages = "1403--1408",

journal = "Cell Death and Differentiation",

issn = "1350-9047",

number = "8",

}

TY - JOUR

T1 - The Bax pore in liposomes, Biophysics

AU - Schlesinger, Paul H.

AU - Saito, M.

PY - 2006/8

Y1 - 2006/8

N2 - The protein BAX of the Bcl-2-family is felt to be one of the two Bcl-2-family proteins that directly participate in the mitochondrial cytochrome c-translocating pore. We have studied the kinetics, stoichiometry and size of the pore formed by BAX in planar lipid bilayers and synthetic liposomes. Our data indicate that a cytochrome c-competent pore can be formed by in-membrane association of BAX monomers.

AB - The protein BAX of the Bcl-2-family is felt to be one of the two Bcl-2-family proteins that directly participate in the mitochondrial cytochrome c-translocating pore. We have studied the kinetics, stoichiometry and size of the pore formed by BAX in planar lipid bilayers and synthetic liposomes. Our data indicate that a cytochrome c-competent pore can be formed by in-membrane association of BAX monomers.

KW - Apoptosis

KW - Bax

KW - Cytochrome c

KW - Pore

UR - http://www.scopus.com/inward/record.url?scp=33745933456&partnerID=8YFLogxK

U2 - 10.1038/sj.cdd.4401991

DO - 10.1038/sj.cdd.4401991

M3 - Review article

C2 - 16763615

AN - SCOPUS:33745933456

SN - 1350-9047

VL - 13

SP - 1403

EP - 1408

JO - Cell Death and Differentiation

JF - Cell Death and Differentiation

IS - 8

ER -

The Bax pore in liposomes, Biophysics

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this