The basis for the immunoregulatory role of macrophages and other accessory cells

Emil R. Unanue, Paul M. Allen

Research output: Contribution to journalReview articlepeer-review

802 Scopus citations

Abstract

Macrophages handle extracellular proteins and secrete diverse bioactive molecules and, therefore, influence the physiology of many tissues. They also have an important immunoregulatory role. The immune response to proteins involves the activation of the T helper subset of lymphocytes. The T helper cell is activated only when it interacts with the protein displayed on the surface of a macrophage or other accessory cell. This interaction involves restrictive proteins encoded in the major histocompatibility gene complex as well as growth-differentiating proteins.

Original languageEnglish
Pages (from-to)551-557
Number of pages7
JournalScience
Volume236
Issue number4801
DOIs
StatePublished - 1987

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