The autism-related protein CHD8 contributes to the stemness and differentiation of mouse hematopoietic stem cells

Akihiro Nita; Yoshiharu Muto; Yuta Katayama; Akinobu Matsumoto; Masaaki Nishiyama; Keiichi I. Nakayama

doi:10.1016/j.celrep.2021.108688

The autism-related protein CHD8 contributes to the stemness and differentiation of mouse hematopoietic stem cells

Akihiro Nita, Yoshiharu Muto, Yuta Katayama, Akinobu Matsumoto, Masaaki Nishiyama, Keiichi I. Nakayama

Division of Nephrology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Nita et al. reveal that the CHD8-p53 axis plays a key role in regulation of the stemness and differentiation of hematopoietic stem cells (HSCs) in vitro and in vivo. CHD8 deficiency in HSCs results in cell cycle arrest, apoptosis, and a differentiation block, which are partially rescued by additional deletion of p53.

Original language	English
Article number	108688
Journal	Cell Reports
Volume	34
Issue number	5
DOIs	https://doi.org/10.1016/j.celrep.2021.108688
State	Published - Feb 2 2021

Keywords

CHD8
apoptosis
bone marrow transplantation
cell cycle arrest
chromatin remodeler
colony formation assay
differentiation block
hematopoietic stem cell
p53
stemness

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10.1016/j.celrep.2021.108688

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title = "The autism-related protein CHD8 contributes to the stemness and differentiation of mouse hematopoietic stem cells",

abstract = "Nita et al. reveal that the CHD8-p53 axis plays a key role in regulation of the stemness and differentiation of hematopoietic stem cells (HSCs) in vitro and in vivo. CHD8 deficiency in HSCs results in cell cycle arrest, apoptosis, and a differentiation block, which are partially rescued by additional deletion of p53.",

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author = "Akihiro Nita and Yoshiharu Muto and Yuta Katayama and Akinobu Matsumoto and Masaaki Nishiyama and Nakayama, {Keiichi I.}",

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AU - Matsumoto, Akinobu

AU - Nishiyama, Masaaki

AU - Nakayama, Keiichi I.

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AB - Nita et al. reveal that the CHD8-p53 axis plays a key role in regulation of the stemness and differentiation of hematopoietic stem cells (HSCs) in vitro and in vivo. CHD8 deficiency in HSCs results in cell cycle arrest, apoptosis, and a differentiation block, which are partially rescued by additional deletion of p53.

KW - CHD8

KW - apoptosis

KW - bone marrow transplantation

KW - cell cycle arrest

KW - chromatin remodeler

KW - colony formation assay

KW - differentiation block

KW - hematopoietic stem cell

KW - p53

KW - stemness

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The autism-related protein CHD8 contributes to the stemness and differentiation of mouse hematopoietic stem cells

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Keywords

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