The Association of Prenatal Vitamin D Sufficiency With Aeroallergen Sensitization and Allergic Rhinitis in Early Childhood

Yih Chieh S. Chen, Hooman Mirzakhani, Mengdi Lu, Robert S. Zeiger, George T. O'Connor, Megan T. Sandel, Leonard B. Bacharier, Avraham Beigelman, Vincent J. Carey, Benjamin J. Harshfield, Nancy Laranjo, Augusto A. Litonjua, Scott T. Weiss, Kathleen A. Lee-Sarwar

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: The role of prenatal vitamin D sufficiency and supplementation in the development of childhood aeroallergen sensitization and allergic rhinitis remains uncertain. Objective: To describe the association of prenatal vitamin D sufficiency with childhood allergic outcomes in participants of the Vitamin D Antenatal Asthma Reduction Trial, a randomized controlled trial of prenatal vitamin D supplementation. Methods: We included 414 mother–offspring pairs with offspring aeroallergen sensitization data available at age 6 years in this analysis. We examined the association between prenatal vitamin D sufficiency status, based on vitamin D levels measured in the first and third trimesters, or vitamin D supplementation treatment assignment with the outcomes of aeroallergen sensitization, parent-reported clinical allergic rhinitis, parent-reported clinical allergic rhinitis with aeroallergen sensitization, food sensitization, any sensitization, eczema, and total IgE at ages 3 and 6 years. Results: Compared with early and late insufficiency, early prenatal vitamin D insufficiency with late sufficiency was associated with reduced development of clinical allergic rhinitis with aeroallergen sensitization at 3 years (adjusted odds ratio [aOR] = 0.34; 95% confidence interval [CI], 0.13-0.82; P =.02) and 6 years (aOR = 0.54; 95% CI, 0.29-0.98; P =.05). At 6 years, clinical allergic rhinitis with sensitization was significantly decreased in offspring whose mothers received high-dose vitamin D (aOR = 0.54; 95% CI, 0.32-0.91; P =.02) compared with offspring whose mothers who received low-dose vitamin D. Associations of prenatal vitamin D with aeroallergen sensitization were strengthened among children who also developed asthma or who had a maternal history of atopy. Conclusions: Among mothers with first-trimester vitamin D insufficiency, we detected a protective effect of third-trimester prenatal vitamin D sufficiency on the development of clinical allergic rhinitis with aeroallergen sensitization at ages 3 and 6 years.

Original languageEnglish
Pages (from-to)3788-3796.e3
JournalJournal of Allergy and Clinical Immunology: In Practice
Volume9
Issue number10
DOIs
StatePublished - Oct 2021

Keywords

  • Aeroallergen sensitization
  • Allergic rhinitis
  • Prenatal
  • Vitamin D

Fingerprint

Dive into the research topics of 'The Association of Prenatal Vitamin D Sufficiency With Aeroallergen Sensitization and Allergic Rhinitis in Early Childhood'. Together they form a unique fingerprint.

Cite this