The association of metformin use with prostate cancer aggressiveness among Black Americans and White Americans in a population-based study

Saira Khan, Jianwen Cai, Matthew E. Nielsen, Melissa A. Troester, James L. Mohler, Elizabeth T.H. Fontham, Laura Farnan, Bettina F. Drake, Andrew F. Olshan, Jeannette T. Bensen

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Purpose: Metformin has been associated with a reduced incidence of prostate cancer and improved prostate cancer outcomes. However, whether race modifies the association between metformin use and prostate cancer aggressiveness remains uncertain. The association between metformin use and prostate cancer aggressiveness was examined separately in Black Americans (Blacks) and White Americans (Whites). Methods: The study population consisted of 305 Black and 195 White research participants with incident prostate cancer and self-reported diabetes from the North Carolina–Louisiana Prostate Cancer Project. High-aggressive prostate cancer was defined using a composite measure of Gleason sum, prostate-specific antigen, and clinical stage. Multivariable logistic regression was used to assess the association between metformin use and high-aggressive prostate cancer at diagnosis, separately among Whites and Blacks, with adjustment for age, screening history, site, education, insurance, and body mass index. Results: Metformin use was associated positively with high-aggressive prostate cancer in Blacks (OR 2.01; 95% CI 1.05, 3.83). By contrast, a weak inverse association between metformin use and high-aggressive prostate cancer was found in Whites (OR 0.80, 95% CI 0.34, 1.85). Conclusions: The association between metformin use and prostate cancer aggressiveness may be modified by race.

Original languageEnglish
Pages (from-to)1143-1150
Number of pages8
JournalCancer Causes and Control
Volume29
Issue number11
DOIs
StatePublished - Nov 1 2018

Keywords

  • Aggressiveness
  • Black Americans
  • Metformin
  • PCaP
  • Prostate cancer

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