The association of metabolic syndrome and QRS|T angle in US adults (NHANES III)

Leanna Delhey, Jing Jin, Susan Thapa, Robert Delongchamp, Mohammed F. Faramawi

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Background: Spatial QRS|T angle is a predictor of cardiovascular events. Those with metabolic syndrome have an increased risk of cardiovascular morbidity and mortality. This study investigated the association between metabolic syndrome and spatial QRS|T angle. Methods: We obtained data from the National Health and Nutritional Examination Survey III on 6,249 adults. We calculated spatial QRS|T angle from the standard 12-lead electrocardiogram and classified it as abnormal, borderline, or normal. We identified metabolic syndrome if at least three of the following were present: abdominal obesity, elevated blood pressure, elevated triglycerides, decreased high-density lipoprotein (HDL), and impaired fasting glucose. We used weighted logistic regression to estimate the effect of metabolic syndrome and its components on QRS|T angle while stratifying by gender and adjusting for age, race, smoking status, heart rate, PR, QT, and QRS interval, and QRS amplitude. Results: Among men and women, metabolic syndrome, the number of components present, elevated blood pressure, and impaired fasting glucose were positively associated with QRS|T angle. Among women, decreased HDL and abdominal obesity were also positively associated with QRS|T angle. Conclusions: This study suggests that persons with metabolic syndrome may be at increased risk for ventricular arrhythmias. The use of spatial QRS|T angle to assess this cardiovascular risk is warranted.

Original languageEnglish
Article numbere12678
JournalAnnals of Noninvasive Electrocardiology
Issue number1
StatePublished - Jan 1 2020


  • cardiac arrhythmias
  • cardiovascular disease
  • electrocardiography
  • metabolic syndrome
  • surveys


Dive into the research topics of 'The association of metabolic syndrome and QRS|T angle in US adults (NHANES III)'. Together they form a unique fingerprint.

Cite this