TY - JOUR
T1 - The Association of Diabetes and Obesity With Prostate Cancer Progression
T2 - HCaP-NC
AU - Khan, Saira
AU - Cai, Jianwen
AU - Nielsen, Matthew E.
AU - Troester, Melissa A.
AU - Mohler, James L.
AU - Fontham, Elizabeth T.H.
AU - Hendrix, Laura H.
AU - Farnan, Laura
AU - Olshan, Andrew F.
AU - Bensen, Jeannette T.
N1 - Funding Information:
The authors thank the staff, advisory committees, and research participants participating in the PCaP and HCaP-NC studies for their important contributions. The North Carolina-Louisiana Prostate Cancer Project (PCaP) and the Health Care Access and Prostate Cancer Treatment in North Carolina (HCaP-NC) study are carried out as collaborative studies supported by the Department of Defense contract DAMD 17-03-2-0052 and the American Cancer Society award RSGT-08-008-01-CPHPS, respectively. Dr. Khan was supported by T32190194 (Colditz) and by the foundation for Barnes Jewish Hospital and by Siteman Cancer Center. This content is solely the responsibility of the authors and does not necessarily represent the official view of the NIH.
Publisher Copyright:
© 2017 Wiley Periodicals, Inc.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - BACKGROUND: The role of race in modifying the association among diabetes, obesity, and prostate cancer (CaP) progression is not well studied. We evaluated diabetes and obesity in association with time to CaP progression in White Americans (Whites) and Black Americans (Blacks). METHODS: Our study sample consisted of 363 White and 284 Black research participants from the Health Care Access and CaP Treatment in North Carolina (HCaP-NC) cohort. The association between self-reported diabetes or obesity and CaP progression (mean follow-up time approximately 5 years) was assessed using Cox proportional hazards modeling, with adjustment for potential confounders. Stratum-specific hazard ratio (HR) estimates for Whites and Blacks were evaluated. RESULTS: Self-reported diabetes was not associated with CaP progression in the cohort as a whole (HR: 0.86, 95%CI: 0.54, 1.35), or among racially defined groups (Whites, HR: 1.03, 95%CI: 0.50, 2.13 or Blacks, HR: 0.77, 95%CI: 0.43, 1.39). Obesity was positively associated with CaP progression among Whites, in models including (HR: 1.79, 95%CI: 1.08, 2.97), and excluding (HR: 1.80, 95%CI: 1.09, 2.96) diabetes as a covariate. No association was observed between obesity and CaP progression in Blacks or the cohort as whole. CONCLUSIONS: Self-reported diabetes was not associated with CaP progression In HCaP-NC. Obesity was associated with CaP progression only among White research participants. Prostate 77:878–887, 2017.
AB - BACKGROUND: The role of race in modifying the association among diabetes, obesity, and prostate cancer (CaP) progression is not well studied. We evaluated diabetes and obesity in association with time to CaP progression in White Americans (Whites) and Black Americans (Blacks). METHODS: Our study sample consisted of 363 White and 284 Black research participants from the Health Care Access and CaP Treatment in North Carolina (HCaP-NC) cohort. The association between self-reported diabetes or obesity and CaP progression (mean follow-up time approximately 5 years) was assessed using Cox proportional hazards modeling, with adjustment for potential confounders. Stratum-specific hazard ratio (HR) estimates for Whites and Blacks were evaluated. RESULTS: Self-reported diabetes was not associated with CaP progression in the cohort as a whole (HR: 0.86, 95%CI: 0.54, 1.35), or among racially defined groups (Whites, HR: 1.03, 95%CI: 0.50, 2.13 or Blacks, HR: 0.77, 95%CI: 0.43, 1.39). Obesity was positively associated with CaP progression among Whites, in models including (HR: 1.79, 95%CI: 1.08, 2.97), and excluding (HR: 1.80, 95%CI: 1.09, 2.96) diabetes as a covariate. No association was observed between obesity and CaP progression in Blacks or the cohort as whole. CONCLUSIONS: Self-reported diabetes was not associated with CaP progression In HCaP-NC. Obesity was associated with CaP progression only among White research participants. Prostate 77:878–887, 2017.
KW - Black American
KW - HCaP-NC
KW - diabetes
KW - obesity
KW - progression
KW - prostate cancer
UR - http://www.scopus.com/inward/record.url?scp=85014494681&partnerID=8YFLogxK
U2 - 10.1002/pros.23342
DO - 10.1002/pros.23342
M3 - Article
C2 - 28261834
AN - SCOPUS:85014494681
SN - 0270-4137
VL - 77
SP - 878
EP - 887
JO - Prostate
JF - Prostate
IS - 8
ER -