TY - JOUR
T1 - The association of diabetes and obesity with prostate cancer aggressiveness among Black Americans and White Americans in a population-based study
AU - Khan, Saira
AU - Cai, Jianwen
AU - Nielsen, Matthew E.
AU - Troester, Melissa A.
AU - Mohler, James L.
AU - Fontham, Elizabeth T.H.
AU - Hendrix, Laura H.
AU - Farnan, Laura
AU - Olshan, Andrew F.
AU - Bensen, Jeannette T.
N1 - Publisher Copyright:
© 2016, Springer International Publishing Switzerland.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Purpose: Few studies have investigated the role of race in the association of diabetes and obesity with prostate cancer aggressiveness. Here we evaluate the independent association between diabetes and obesity with prostate cancer aggressiveness in White Americans and Black Americans. Methods: Our cross-sectional, case-only study consisted of 1,058 White Americans and 991 Black Americans from the North Carolina-Louisiana Prostate Cancer (PCaP) project. Diabetes status was determined by self-report. Obesity was determined using body mass index and calculated based on anthropometric measurements. High aggressive prostate cancer was defined as Gleason sum ≥8, or prostate-specific antigen >20 ng/ml, or Gleason sum = 7 and clinical stage cT3–cT4. The association between diabetes and obesity with high aggressive prostate cancer at diagnosis was evaluated using multivariable logistic regression and adjusted for potential confounders. Results: Diabetes was not associated with high aggressive prostate cancer in the overall sample (OR 1.04; 95% CI 0.79, 1.37), White Americans (OR 1.00; 95% CI 0.65, 1.57) or Black Americans (OR 1.07; 95% CI 0.75, 1.53). Obesity, independent of diabetes, was positively associated with high aggressive prostate cancer in White Americans (OR 1.98; 95% CI 1.14, 3.43), but not in the overall sample (OR 1.37; 95% CI 0.99, 1.92) or Black Americans (OR 1.09; 95% CI 0.71, 1.67). Conclusions: Diabetes was not associated with prostate cancer aggressiveness, overall, or in either race group. Obesity, independent of diabetes, was associated with high aggressive prostate cancer only in White Americans.
AB - Purpose: Few studies have investigated the role of race in the association of diabetes and obesity with prostate cancer aggressiveness. Here we evaluate the independent association between diabetes and obesity with prostate cancer aggressiveness in White Americans and Black Americans. Methods: Our cross-sectional, case-only study consisted of 1,058 White Americans and 991 Black Americans from the North Carolina-Louisiana Prostate Cancer (PCaP) project. Diabetes status was determined by self-report. Obesity was determined using body mass index and calculated based on anthropometric measurements. High aggressive prostate cancer was defined as Gleason sum ≥8, or prostate-specific antigen >20 ng/ml, or Gleason sum = 7 and clinical stage cT3–cT4. The association between diabetes and obesity with high aggressive prostate cancer at diagnosis was evaluated using multivariable logistic regression and adjusted for potential confounders. Results: Diabetes was not associated with high aggressive prostate cancer in the overall sample (OR 1.04; 95% CI 0.79, 1.37), White Americans (OR 1.00; 95% CI 0.65, 1.57) or Black Americans (OR 1.07; 95% CI 0.75, 1.53). Obesity, independent of diabetes, was positively associated with high aggressive prostate cancer in White Americans (OR 1.98; 95% CI 1.14, 3.43), but not in the overall sample (OR 1.37; 95% CI 0.99, 1.92) or Black Americans (OR 1.09; 95% CI 0.71, 1.67). Conclusions: Diabetes was not associated with prostate cancer aggressiveness, overall, or in either race group. Obesity, independent of diabetes, was associated with high aggressive prostate cancer only in White Americans.
KW - Aggressiveness
KW - Black Americans
KW - Diabetes
KW - Obesity
KW - PCaP
KW - Prostrate cancer
UR - http://www.scopus.com/inward/record.url?scp=84994475208&partnerID=8YFLogxK
U2 - 10.1007/s10552-016-0828-0
DO - 10.1007/s10552-016-0828-0
M3 - Article
C2 - 27830399
AN - SCOPUS:84994475208
SN - 0957-5243
VL - 27
SP - 1475
EP - 1485
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 12
ER -