The association of caregiver attitudes, information sources, and trust with HPV vaccine initiation among adolescents

Akila Anandarajah, Thembekile Shato, Sarah Humble, Alan R. Barnette, Heather M. Brandt, Lisa M. Klesges, Vetta L. Sanders Thompson, Michelle I. Silver

Research output: Contribution to journalArticlepeer-review


This study described caregiver attitudes and the information sources they access about HPV vaccination for adolescents and determined their influence on human papillomavirus (HPV) vaccination initiation. An online survey was administered to 1,016 adults in July 2021. Participants were eligible if they were the caregiver of a child aged 9–17 residing in Mississippi, Arkansas, Tennessee, Missouri, and select counties in Southern Illinois. Multivariate logistic regression was used to estimate the association of caregiver attitudes and information sources with HPV vaccination. Information from doctors or healthcare providers (87.4%) and internet sources other than social media (31.0%) were the most used sources for HPV vaccine information. The highest proportion of caregivers trusted their doctor or healthcare providers (92.4%) and family or friends (68.5%) as sources of information. The HPV vaccine series was more likely to be initiated in children whose caregivers agreed that the vaccine is beneficial (AOR = 4.39, 95% CI = 2.05, 9.39), but less likely with caregivers who were concerned about side effects (AOR = 0.61, 95% CI = 0.42, 0.88) and who received HPV vaccination information from family or friends (AOR = 0.57, 95% CI = 0.35, 0.93). This study found that caregivers’ attitudes, information sources, and trust in those sources were associated with their adolescent’s HPV vaccination status. These findings highlight the need to address attitudes and information sources and suggest that tailored interventions considering these factors could increase HPV vaccination rates.

Original languageEnglish
Article number2300879
JournalHuman Vaccines and Immunotherapeutics
Issue number1
StatePublished - 2024


  • HPV vaccine
  • adolescents
  • attitudes
  • caregivers
  • children
  • information sources
  • trust


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