The Association of Alcohol Consumption with Glaucoma and Related Traits: Findings from the UK Biobank

Members of the International Glaucoma Genetics Consortium; Modifiable Risk Factors for Glaucoma Collaboration, the UK Biobank Eye and Vision Consortium, and the International Glaucoma Genetics Consortium; Members of the Modifiable Risk Factors for Glaucoma Collaboration; Members of the UK Biobank Eye and Vision Consortium; Kelsey V. Stuart; Robert N. Luben; Alasdair N. Warwick; Kian M. Madjedi; Praveen J. Patel; Mahantesh I. Biradar; Zihan Sun; Mark A. Chia; Louis R. Pasquale; Janey L. Wiggs; Jae H. Kang; Jihye Kim; Hugues Aschard; Jessica H. Tran; Marleen A.H. Lentjes; Paul J. Foster; Anthony P. Khawaja; Mark Chia; Sharon Chua; Ron Do; Paul Foster; Jae Kang; Alan Kastner; Anthony Khawaja; Marleen Lentjes; Robert Luben; Kian Madjedi; Giovanni Montesano; Louis Pasquale; Alasdair Warwick; Janey Wiggs; Naomi Allen; Tariq Aslam; Denize Atan; Sarah Barman; Jenny Barrett; Paul Bishop; Graeme Black; Tasanee Braithwaite; Roxana Carare; Usha Chakravarthy; Michelle Chan; Alexander Day; Parul Desai; Bal Dhillon; Andrew Dick; Alexander Doney; Cathy Egan; Sarah Ennis; Marcus Fruttiger; John Gallacher; David (Ted) Garway-Heath; Jane Gibson; Jeremy Guggenheim; Chris Hammond; Alison Hardcastle; Simon Harding; Ruth Hogg; Pirro Hysi; Pearse Keane; Peng Tee Khaw; Gerassimos Lascaratos; Thomas Littlejohns; Andrew Lotery; Phil Luthert; Tom MacGillivray; Sarah Mackie; Bernadette McGuinness; Gareth McKay; Martin McKibbin; Tony Moore; James Morgan; Eoin O'Sullivan; Richard Oram; Chris Owen; Praveen Patel; Euan Paterson; Tunde Peto; Axel Petzold; Nikolas Pontikos; Jugnoo Rahi; Alicja Rudnicka; Naveed Sattar; Jay Self; Panagiotis Sergouniotis; Sobha Sivaprasad; David Steel; Irene Stratton; Nicholas Strouthidis; Cathie Sudlow; Robyn Tapp; Dhanes Thomas; Emanuele Trucco; Adnan Tufail; Ananth Viswanathan; Veronique Vitart; Mike Weedon; Katie Williams; Cathy Williams; Jayne Woodside; Max Yates; Jennifer Yip; Yalin Zheng; Tin Aung; Kathryn Burdon; Li Chen; Ching Yu Cheng; Jamie Craig; Angela Cree; Victor de Vries; Sjoerd Driessen; John Fingert; Puya Gharahkhani; Christopher Hammond; Caroline Hayward; Alex Hewitt; Nomdo Jansonius; Fridbert Jonansson; Jost Jonas; Michael Kass; Chiea Khor; Caroline Klaver; Jacyline Koh; Stuart MacGregor; David Mackey; Paul Mitchell; Calvin Pang; Francesca Pasutto; Norbert Pfeiffer; Ozren Polašek; Wishal Ramdas; Alexander Schuster; Ayellet Segrè; Einer Stefansson; Kári Stefánsson; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Cornelia van Duijn; Joëlle Vergroesen; Eranga Vithana; James Wilson; Robert Wojciechowski; Tien Wong; Terri Young

doi:10.1016/j.ogla.2022.11.008

The Association of Alcohol Consumption with Glaucoma and Related Traits: Findings from the UK Biobank

Members of the International Glaucoma Genetics Consortium, Modifiable Risk Factors for Glaucoma Collaboration, the UK Biobank Eye and Vision Consortium, and the International Glaucoma Genetics Consortium, Members of the Modifiable Risk Factors for Glaucoma Collaboration, Members of the UK Biobank Eye and Vision Consortium, Kelsey V. Stuart, Robert N. Luben, Alasdair N. Warwick, Kian M. Madjedi, Praveen J. Patel, Mahantesh I. Biradar, Zihan Sun, Mark A. Chia, Louis R. Pasquale, Janey L. Wiggs, Jae H. Kang, Jihye Kim, Hugues Aschard, Jessica H. Tran, Marleen A.H. Lentjes, Paul J. FosterAnthony P. Khawaja, Mark Chia, Sharon Chua, Ron Do, Paul Foster, Jae Kang, Alan Kastner, Anthony Khawaja, Marleen Lentjes, Robert Luben, Kian Madjedi, Giovanni Montesano, Louis Pasquale, Alasdair Warwick, Janey Wiggs, Naomi Allen, Tariq Aslam, Denize Atan, Sarah Barman, Jenny Barrett, Paul Bishop, Graeme Black, Tasanee Braithwaite, Roxana Carare, Usha Chakravarthy, Michelle Chan, Alexander Day, Parul Desai, Bal Dhillon, Andrew Dick, Alexander Doney, Cathy Egan, Sarah Ennis, Marcus Fruttiger, John Gallacher, David (Ted) Garway-Heath, Jane Gibson, Jeremy Guggenheim, Chris Hammond, Alison Hardcastle, Simon Harding, Ruth Hogg, Pirro Hysi, Pearse Keane, Peng Tee Khaw, Gerassimos Lascaratos, Thomas Littlejohns, Andrew Lotery, Phil Luthert, Tom MacGillivray, Sarah Mackie, Bernadette McGuinness, Gareth McKay, Martin McKibbin, Tony Moore, James Morgan, Eoin O'Sullivan, Richard Oram, Chris Owen, Praveen Patel, Euan Paterson, Tunde Peto, Axel Petzold, Nikolas Pontikos, Jugnoo Rahi, Alicja Rudnicka, Naveed Sattar, Jay Self, Panagiotis Sergouniotis, Sobha Sivaprasad, David Steel, Irene Stratton, Nicholas Strouthidis, Cathie Sudlow, Robyn Tapp, Dhanes Thomas, Emanuele Trucco, Adnan Tufail, Ananth Viswanathan, Veronique Vitart, Mike Weedon, Katie Williams, Cathy Williams, Jayne Woodside, Max Yates, Jennifer Yip, Yalin Zheng, Tin Aung, Kathryn Burdon, Li Chen, Ching Yu Cheng, Jamie Craig, Angela Cree, Victor de Vries, Sjoerd Driessen, John Fingert, Puya Gharahkhani, Christopher Hammond, Caroline Hayward, Alex Hewitt, Nomdo Jansonius, Fridbert Jonansson, Jost Jonas, Michael Kass, Chiea Khor, Caroline Klaver, Jacyline Koh, Stuart MacGregor, David Mackey, Paul Mitchell, Calvin Pang, Francesca Pasutto, Norbert Pfeiffer, Ozren Polašek, Wishal Ramdas, Alexander Schuster, Ayellet Segrè, Einer Stefansson, Kári Stefánsson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Cornelia van Duijn, Joëlle Vergroesen, Eranga Vithana, James Wilson, Robert Wojciechowski, Tien Wong, Terri Young

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Purpose: To examine the associations of alcohol consumption with glaucoma and related traits, to assess whether a genetic predisposition to glaucoma modified these associations, and to perform Mendelian randomization (MR) experiments to probe causal effects. Design: Cross-sectional observational and gene–environment interaction analyses in the UK Biobank. Two-sample MR experiments using summary statistics from large genetic consortia. Participants: UK Biobank participants with data on intraocular pressure (IOP) (n = 109 097), OCT-derived macular inner retinal layer thickness measures (n = 46 236) and glaucoma status (n = 173 407). Methods: Participants were categorized according to self-reported drinking behaviors. Quantitative estimates of alcohol intake were derived from touchscreen questionnaires and food composition tables. We performed a 2-step analysis, first comparing categories of alcohol consumption (never, infrequent, regular, and former drinkers) before assessing for a dose-response effect in regular drinkers only. Multivariable linear, logistic, and restricted cubic spline regression, adjusted for key sociodemographic, medical, anthropometric, and lifestyle factors, were used to examine associations. We assessed whether any association was modified by a multitrait glaucoma polygenic risk score. The inverse-variance weighted method was used for the main MR analyses. Main Outcome Measures: Intraocular pressure, macular retinal nerve fiber layer (mRNFL) thickness, macular ganglion cell–inner plexiform layer (mGCIPL) thickness, and prevalent glaucoma. Results: Compared with infrequent drinkers, regular drinkers had higher IOP (+0.17 mmHg; P < 0.001) and thinner mGCIPL (-0.17 μm; P = 0.049), whereas former drinkers had a higher prevalence of glaucoma (odds ratio, 1.53; P = 0.002). In regular drinkers, alcohol intake was adversely associated with all outcomes in a dose-dependent manner (all P < 0.001). Restricted cubic spline regression analyses suggested nonlinear associations, with apparent threshold effects at approximately 50 g (∼6 UK or 4 US alcoholic units)/week for mRNFL and mGCIPL thickness. Significantly stronger alcohol–IOP associations were observed in participants at higher genetic susceptibility to glaucoma (P_interaction < 0.001). Mendelian randomization analyses provided evidence for a causal association with mGCIPL thickness. Conclusions: Alcohol intake was consistently and adversely associated with glaucoma and related traits, and at levels below current United Kingdom (< 112 g/week) and United States (women, < 98 g/week; men, < 196 g/week) guidelines. Although we cannot infer causality definitively, these results will be of interest to people with or at risk of glaucoma and their advising physicians. Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references.

Original language	English
Pages (from-to)	366-379
Number of pages	14
Journal	Ophthalmology. Glaucoma
Volume	6
Issue number	4
DOIs	https://doi.org/10.1016/j.ogla.2022.11.008
State	Published - Jul 1 2023

Keywords

Alcohol
Glaucoma
Intraocular pressure
OCT
UK Biobank

Access to Document

10.1016/j.ogla.2022.11.008

Cite this

Members of the International Glaucoma Genetics Consortium, Modifiable Risk Factors for Glaucoma Collaboration, the UK Biobank Eye and Vision Consortium, and the International Glaucoma Genetics Consortium, Members of the Modifiable Risk Factors for Glaucoma Collaboration, Members of the UK Biobank Eye and Vision Consortium, Stuart, K. V., Luben, R. N., Warwick, A. N., Madjedi, K. M., Patel, P. J., Biradar, M. I., Sun, Z., Chia, M. A., Pasquale, L. R., Wiggs, J. L., Kang, J. H., Kim, J., Aschard, H., Tran, J. H., Lentjes, M. A. H., ... Young, T. (2023). The Association of Alcohol Consumption with Glaucoma and Related Traits: Findings from the UK Biobank. Ophthalmology. Glaucoma, 6(4), 366-379. https://doi.org/10.1016/j.ogla.2022.11.008

Members of the International Glaucoma Genetics Consortium ; Modifiable Risk Factors for Glaucoma Collaboration, the UK Biobank Eye and Vision Consortium, and the International Glaucoma Genetics Consortium ; Members of the Modifiable Risk Factors for Glaucoma Collaboration et al. / The Association of Alcohol Consumption with Glaucoma and Related Traits : Findings from the UK Biobank. In: Ophthalmology. Glaucoma. 2023 ; Vol. 6, No. 4. pp. 366-379.

@article{336276827ce046cba7919f52158bfd9b,

title = "The Association of Alcohol Consumption with Glaucoma and Related Traits: Findings from the UK Biobank",

abstract = "Purpose: To examine the associations of alcohol consumption with glaucoma and related traits, to assess whether a genetic predisposition to glaucoma modified these associations, and to perform Mendelian randomization (MR) experiments to probe causal effects. Design: Cross-sectional observational and gene–environment interaction analyses in the UK Biobank. Two-sample MR experiments using summary statistics from large genetic consortia. Participants: UK Biobank participants with data on intraocular pressure (IOP) (n = 109 097), OCT-derived macular inner retinal layer thickness measures (n = 46 236) and glaucoma status (n = 173 407). Methods: Participants were categorized according to self-reported drinking behaviors. Quantitative estimates of alcohol intake were derived from touchscreen questionnaires and food composition tables. We performed a 2-step analysis, first comparing categories of alcohol consumption (never, infrequent, regular, and former drinkers) before assessing for a dose-response effect in regular drinkers only. Multivariable linear, logistic, and restricted cubic spline regression, adjusted for key sociodemographic, medical, anthropometric, and lifestyle factors, were used to examine associations. We assessed whether any association was modified by a multitrait glaucoma polygenic risk score. The inverse-variance weighted method was used for the main MR analyses. Main Outcome Measures: Intraocular pressure, macular retinal nerve fiber layer (mRNFL) thickness, macular ganglion cell–inner plexiform layer (mGCIPL) thickness, and prevalent glaucoma. Results: Compared with infrequent drinkers, regular drinkers had higher IOP (+0.17 mmHg; P < 0.001) and thinner mGCIPL (-0.17 μm; P = 0.049), whereas former drinkers had a higher prevalence of glaucoma (odds ratio, 1.53; P = 0.002). In regular drinkers, alcohol intake was adversely associated with all outcomes in a dose-dependent manner (all P < 0.001). Restricted cubic spline regression analyses suggested nonlinear associations, with apparent threshold effects at approximately 50 g (∼6 UK or 4 US alcoholic units)/week for mRNFL and mGCIPL thickness. Significantly stronger alcohol–IOP associations were observed in participants at higher genetic susceptibility to glaucoma (Pinteraction < 0.001). Mendelian randomization analyses provided evidence for a causal association with mGCIPL thickness. Conclusions: Alcohol intake was consistently and adversely associated with glaucoma and related traits, and at levels below current United Kingdom (< 112 g/week) and United States (women, < 98 g/week; men, < 196 g/week) guidelines. Although we cannot infer causality definitively, these results will be of interest to people with or at risk of glaucoma and their advising physicians. Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references.",

keywords = "Alcohol, Glaucoma, Intraocular pressure, OCT, UK Biobank",

author = "{Members of the International Glaucoma Genetics Consortium} and {Modifiable Risk Factors for Glaucoma Collaboration, the UK Biobank Eye and Vision Consortium, and the International Glaucoma Genetics Consortium} and {Members of the Modifiable Risk Factors for Glaucoma Collaboration} and {Members of the UK Biobank Eye and Vision Consortium} and Stuart, {Kelsey V.} and Luben, {Robert N.} and Warwick, {Alasdair N.} and Madjedi, {Kian M.} and Patel, {Praveen J.} and Biradar, {Mahantesh I.} and Zihan Sun and Chia, {Mark A.} and Pasquale, {Louis R.} and Wiggs, {Janey L.} and Kang, {Jae H.} and Jihye Kim and Hugues Aschard and Tran, {Jessica H.} and Lentjes, {Marleen A.H.} and Foster, {Paul J.} and Khawaja, {Anthony P.} and Mark Chia and Sharon Chua and Ron Do and Paul Foster and Jae Kang and Alan Kastner and Anthony Khawaja and Marleen Lentjes and Robert Luben and Kian Madjedi and Giovanni Montesano and Louis Pasquale and Alasdair Warwick and Janey Wiggs and Naomi Allen and Tariq Aslam and Denize Atan and Sarah Barman and Jenny Barrett and Paul Bishop and Graeme Black and Tasanee Braithwaite and Roxana Carare and Usha Chakravarthy and Michelle Chan and Alexander Day and Parul Desai and Bal Dhillon and Andrew Dick and Alexander Doney and Cathy Egan and Sarah Ennis and Marcus Fruttiger and John Gallacher and Garway-Heath, {David (Ted)} and Jane Gibson and Jeremy Guggenheim and Chris Hammond and Alison Hardcastle and Simon Harding and Ruth Hogg and Pirro Hysi and Pearse Keane and Khaw, {Peng Tee} and Gerassimos Lascaratos and Thomas Littlejohns and Andrew Lotery and Phil Luthert and Tom MacGillivray and Sarah Mackie and Bernadette McGuinness and Gareth McKay and Martin McKibbin and Tony Moore and James Morgan and Eoin O'Sullivan and Richard Oram and Chris Owen and Praveen Patel and Euan Paterson and Tunde Peto and Axel Petzold and Nikolas Pontikos and Jugnoo Rahi and Alicja Rudnicka and Naveed Sattar and Jay Self and Panagiotis Sergouniotis and Sobha Sivaprasad and David Steel and Irene Stratton and Nicholas Strouthidis and Cathie Sudlow and Robyn Tapp and Dhanes Thomas and Emanuele Trucco and Adnan Tufail and Ananth Viswanathan and Veronique Vitart and Mike Weedon and Katie Williams and Cathy Williams and Jayne Woodside and Max Yates and Jennifer Yip and Yalin Zheng and Tin Aung and Kathryn Burdon and Li Chen and Cheng, {Ching Yu} and Jamie Craig and Angela Cree and {de Vries}, Victor and Sjoerd Driessen and John Fingert and Puya Gharahkhani and Christopher Hammond and Caroline Hayward and Alex Hewitt and Nomdo Jansonius and Fridbert Jonansson and Jost Jonas and Michael Kass and Chiea Khor and Caroline Klaver and Jacyline Koh and Stuart MacGregor and David Mackey and Paul Mitchell and Calvin Pang and Francesca Pasutto and Norbert Pfeiffer and Ozren Pola{\v s}ek and Wishal Ramdas and Alexander Schuster and Ayellet Segr{\`e} and Einer Stefansson and K{\'a}ri Stef{\'a}nsson and Gudmar Thorleifsson and Unnur Thorsteinsdottir and {van Duijn}, Cornelia and Jo{\"e}lle Vergroesen and Eranga Vithana and James Wilson and Robert Wojciechowski and Tien Wong and Terri Young",

note = "Publisher Copyright: {\textcopyright} 2022 American Academy of Ophthalmology",

year = "2023",

month = jul,

day = "1",

doi = "10.1016/j.ogla.2022.11.008",

language = "English",

volume = "6",

pages = "366--379",

journal = "Ophthalmology. Glaucoma",

issn = "2589-4234",

number = "4",

}

Members of the International Glaucoma Genetics Consortium, Modifiable Risk Factors for Glaucoma Collaboration, the UK Biobank Eye and Vision Consortium, and the International Glaucoma Genetics Consortium, Members of the Modifiable Risk Factors for Glaucoma Collaboration, Members of the UK Biobank Eye and Vision Consortium, Stuart, KV, Luben, RN, Warwick, AN, Madjedi, KM, Patel, PJ, Biradar, MI, Sun, Z, Chia, MA, Pasquale, LR, Wiggs, JL, Kang, JH, Kim, J, Aschard, H, Tran, JH, Lentjes, MAH, Foster, PJ, Khawaja, AP, Chia, M, Chua, S, Do, R, Foster, P, Kang, J, Kastner, A, Khawaja, A, Lentjes, M, Luben, R, Madjedi, K, Montesano, G, Pasquale, L, Warwick, A, Wiggs, J, Allen, N, Aslam, T, Atan, D, Barman, S, Barrett, J, Bishop, P, Black, G, Braithwaite, T, Carare, R, Chakravarthy, U, Chan, M, Day, A, Desai, P, Dhillon, B, Dick, A, Doney, A, Egan, C, Ennis, S, Fruttiger, M, Gallacher, J, Garway-Heath, D, Gibson, J, Guggenheim, J, Hammond, C, Hardcastle, A, Harding, S, Hogg, R, Hysi, P, Keane, P, Khaw, PT, Lascaratos, G, Littlejohns, T, Lotery, A, Luthert, P, MacGillivray, T, Mackie, S, McGuinness, B, McKay, G, McKibbin, M, Moore, T, Morgan, J, O'Sullivan, E, Oram, R, Owen, C, Patel, P, Paterson, E, Peto, T, Petzold, A, Pontikos, N, Rahi, J, Rudnicka, A, Sattar, N, Self, J, Sergouniotis, P, Sivaprasad, S, Steel, D, Stratton, I, Strouthidis, N, Sudlow, C, Tapp, R, Thomas, D, Trucco, E, Tufail, A, Viswanathan, A, Vitart, V, Weedon, M, Williams, K, Williams, C, Woodside, J, Yates, M, Yip, J, Zheng, Y, Aung, T, Burdon, K, Chen, L, Cheng, CY, Craig, J, Cree, A, de Vries, V, Driessen, S, Fingert, J, Gharahkhani, P, Hammond, C, Hayward, C, Hewitt, A, Jansonius, N, Jonansson, F, Jonas, J, Kass, M, Khor, C, Klaver, C, Koh, J, MacGregor, S, Mackey, D, Mitchell, P, Pang, C, Pasutto, F, Pfeiffer, N, Polašek, O, Ramdas, W, Schuster, A, Segrè, A, Stefansson, E, Stefánsson, K, Thorleifsson, G, Thorsteinsdottir, U, van Duijn, C, Vergroesen, J, Vithana, E, Wilson, J, Wojciechowski, R, Wong, T & Young, T 2023, 'The Association of Alcohol Consumption with Glaucoma and Related Traits: Findings from the UK Biobank', Ophthalmology. Glaucoma, vol. 6, no. 4, pp. 366-379. https://doi.org/10.1016/j.ogla.2022.11.008

The Association of Alcohol Consumption with Glaucoma and Related Traits: Findings from the UK Biobank. / Members of the International Glaucoma Genetics Consortium; Modifiable Risk Factors for Glaucoma Collaboration, the UK Biobank Eye and Vision Consortium, and the International Glaucoma Genetics Consortium; Members of the Modifiable Risk Factors for Glaucoma Collaboration et al.
In: Ophthalmology. Glaucoma, Vol. 6, No. 4, 01.07.2023, p. 366-379.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The Association of Alcohol Consumption with Glaucoma and Related Traits

T2 - Findings from the UK Biobank

AU - Members of the International Glaucoma Genetics Consortium

AU - Modifiable Risk Factors for Glaucoma Collaboration, the UK Biobank Eye and Vision Consortium, and the International Glaucoma Genetics Consortium

AU - Members of the Modifiable Risk Factors for Glaucoma Collaboration

AU - Members of the UK Biobank Eye and Vision Consortium

AU - Stuart, Kelsey V.

AU - Luben, Robert N.

AU - Warwick, Alasdair N.

AU - Madjedi, Kian M.

AU - Patel, Praveen J.

AU - Biradar, Mahantesh I.

AU - Sun, Zihan

AU - Chia, Mark A.

AU - Pasquale, Louis R.

AU - Wiggs, Janey L.

AU - Kang, Jae H.

AU - Kim, Jihye

AU - Aschard, Hugues

AU - Tran, Jessica H.

AU - Lentjes, Marleen A.H.

AU - Foster, Paul J.

AU - Khawaja, Anthony P.

AU - Chia, Mark

AU - Chua, Sharon

AU - Do, Ron

AU - Foster, Paul

AU - Kang, Jae

AU - Kastner, Alan

AU - Khawaja, Anthony

AU - Lentjes, Marleen

AU - Luben, Robert

AU - Madjedi, Kian

AU - Montesano, Giovanni

AU - Pasquale, Louis

AU - Warwick, Alasdair

AU - Wiggs, Janey

AU - Allen, Naomi

AU - Aslam, Tariq

AU - Atan, Denize

AU - Barman, Sarah

AU - Barrett, Jenny

AU - Bishop, Paul

AU - Black, Graeme

AU - Braithwaite, Tasanee

AU - Carare, Roxana

AU - Chakravarthy, Usha

AU - Chan, Michelle

AU - Day, Alexander

AU - Desai, Parul

AU - Dhillon, Bal

AU - Dick, Andrew

AU - Doney, Alexander

AU - Egan, Cathy

AU - Ennis, Sarah

AU - Fruttiger, Marcus

AU - Gallacher, John

AU - Garway-Heath, David (Ted)

AU - Gibson, Jane

AU - Guggenheim, Jeremy

AU - Hammond, Chris

AU - Hardcastle, Alison

AU - Harding, Simon

AU - Hogg, Ruth

AU - Hysi, Pirro

AU - Keane, Pearse

AU - Khaw, Peng Tee

AU - Lascaratos, Gerassimos

AU - Littlejohns, Thomas

AU - Lotery, Andrew

AU - Luthert, Phil

AU - MacGillivray, Tom

AU - Mackie, Sarah

AU - McGuinness, Bernadette

AU - McKay, Gareth

AU - McKibbin, Martin

AU - Moore, Tony

AU - Morgan, James

AU - O'Sullivan, Eoin

AU - Oram, Richard

AU - Owen, Chris

AU - Patel, Praveen

AU - Paterson, Euan

AU - Peto, Tunde

AU - Petzold, Axel

AU - Pontikos, Nikolas

AU - Rahi, Jugnoo

AU - Rudnicka, Alicja

AU - Sattar, Naveed

AU - Self, Jay

AU - Sergouniotis, Panagiotis

AU - Sivaprasad, Sobha

AU - Steel, David

AU - Stratton, Irene

AU - Strouthidis, Nicholas

AU - Sudlow, Cathie

AU - Tapp, Robyn

AU - Thomas, Dhanes

AU - Trucco, Emanuele

AU - Tufail, Adnan

AU - Viswanathan, Ananth

AU - Vitart, Veronique

AU - Weedon, Mike

AU - Williams, Katie

AU - Williams, Cathy

AU - Woodside, Jayne

AU - Yates, Max

AU - Yip, Jennifer

AU - Zheng, Yalin

AU - Aung, Tin

AU - Burdon, Kathryn

AU - Chen, Li

AU - Cheng, Ching Yu

AU - Craig, Jamie

AU - Cree, Angela

AU - de Vries, Victor

AU - Driessen, Sjoerd

AU - Fingert, John

AU - Gharahkhani, Puya

AU - Hammond, Christopher

AU - Hayward, Caroline

AU - Hewitt, Alex

AU - Jansonius, Nomdo

AU - Jonansson, Fridbert

AU - Jonas, Jost

AU - Kass, Michael

AU - Khor, Chiea

AU - Klaver, Caroline

AU - Koh, Jacyline

AU - MacGregor, Stuart

AU - Mackey, David

AU - Mitchell, Paul

AU - Pang, Calvin

AU - Pasutto, Francesca

AU - Pfeiffer, Norbert

AU - Polašek, Ozren

AU - Ramdas, Wishal

AU - Schuster, Alexander

AU - Segrè, Ayellet

AU - Stefansson, Einer

AU - Stefánsson, Kári

AU - Thorleifsson, Gudmar

AU - Thorsteinsdottir, Unnur

AU - van Duijn, Cornelia

AU - Vergroesen, Joëlle

AU - Vithana, Eranga

AU - Wilson, James

AU - Wojciechowski, Robert

AU - Wong, Tien

AU - Young, Terri

PY - 2023/7/1

Y1 - 2023/7/1

N2 - Purpose: To examine the associations of alcohol consumption with glaucoma and related traits, to assess whether a genetic predisposition to glaucoma modified these associations, and to perform Mendelian randomization (MR) experiments to probe causal effects. Design: Cross-sectional observational and gene–environment interaction analyses in the UK Biobank. Two-sample MR experiments using summary statistics from large genetic consortia. Participants: UK Biobank participants with data on intraocular pressure (IOP) (n = 109 097), OCT-derived macular inner retinal layer thickness measures (n = 46 236) and glaucoma status (n = 173 407). Methods: Participants were categorized according to self-reported drinking behaviors. Quantitative estimates of alcohol intake were derived from touchscreen questionnaires and food composition tables. We performed a 2-step analysis, first comparing categories of alcohol consumption (never, infrequent, regular, and former drinkers) before assessing for a dose-response effect in regular drinkers only. Multivariable linear, logistic, and restricted cubic spline regression, adjusted for key sociodemographic, medical, anthropometric, and lifestyle factors, were used to examine associations. We assessed whether any association was modified by a multitrait glaucoma polygenic risk score. The inverse-variance weighted method was used for the main MR analyses. Main Outcome Measures: Intraocular pressure, macular retinal nerve fiber layer (mRNFL) thickness, macular ganglion cell–inner plexiform layer (mGCIPL) thickness, and prevalent glaucoma. Results: Compared with infrequent drinkers, regular drinkers had higher IOP (+0.17 mmHg; P < 0.001) and thinner mGCIPL (-0.17 μm; P = 0.049), whereas former drinkers had a higher prevalence of glaucoma (odds ratio, 1.53; P = 0.002). In regular drinkers, alcohol intake was adversely associated with all outcomes in a dose-dependent manner (all P < 0.001). Restricted cubic spline regression analyses suggested nonlinear associations, with apparent threshold effects at approximately 50 g (∼6 UK or 4 US alcoholic units)/week for mRNFL and mGCIPL thickness. Significantly stronger alcohol–IOP associations were observed in participants at higher genetic susceptibility to glaucoma (Pinteraction < 0.001). Mendelian randomization analyses provided evidence for a causal association with mGCIPL thickness. Conclusions: Alcohol intake was consistently and adversely associated with glaucoma and related traits, and at levels below current United Kingdom (< 112 g/week) and United States (women, < 98 g/week; men, < 196 g/week) guidelines. Although we cannot infer causality definitively, these results will be of interest to people with or at risk of glaucoma and their advising physicians. Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references.

AB - Purpose: To examine the associations of alcohol consumption with glaucoma and related traits, to assess whether a genetic predisposition to glaucoma modified these associations, and to perform Mendelian randomization (MR) experiments to probe causal effects. Design: Cross-sectional observational and gene–environment interaction analyses in the UK Biobank. Two-sample MR experiments using summary statistics from large genetic consortia. Participants: UK Biobank participants with data on intraocular pressure (IOP) (n = 109 097), OCT-derived macular inner retinal layer thickness measures (n = 46 236) and glaucoma status (n = 173 407). Methods: Participants were categorized according to self-reported drinking behaviors. Quantitative estimates of alcohol intake were derived from touchscreen questionnaires and food composition tables. We performed a 2-step analysis, first comparing categories of alcohol consumption (never, infrequent, regular, and former drinkers) before assessing for a dose-response effect in regular drinkers only. Multivariable linear, logistic, and restricted cubic spline regression, adjusted for key sociodemographic, medical, anthropometric, and lifestyle factors, were used to examine associations. We assessed whether any association was modified by a multitrait glaucoma polygenic risk score. The inverse-variance weighted method was used for the main MR analyses. Main Outcome Measures: Intraocular pressure, macular retinal nerve fiber layer (mRNFL) thickness, macular ganglion cell–inner plexiform layer (mGCIPL) thickness, and prevalent glaucoma. Results: Compared with infrequent drinkers, regular drinkers had higher IOP (+0.17 mmHg; P < 0.001) and thinner mGCIPL (-0.17 μm; P = 0.049), whereas former drinkers had a higher prevalence of glaucoma (odds ratio, 1.53; P = 0.002). In regular drinkers, alcohol intake was adversely associated with all outcomes in a dose-dependent manner (all P < 0.001). Restricted cubic spline regression analyses suggested nonlinear associations, with apparent threshold effects at approximately 50 g (∼6 UK or 4 US alcoholic units)/week for mRNFL and mGCIPL thickness. Significantly stronger alcohol–IOP associations were observed in participants at higher genetic susceptibility to glaucoma (Pinteraction < 0.001). Mendelian randomization analyses provided evidence for a causal association with mGCIPL thickness. Conclusions: Alcohol intake was consistently and adversely associated with glaucoma and related traits, and at levels below current United Kingdom (< 112 g/week) and United States (women, < 98 g/week; men, < 196 g/week) guidelines. Although we cannot infer causality definitively, these results will be of interest to people with or at risk of glaucoma and their advising physicians. Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references.

KW - Alcohol

KW - Glaucoma

KW - Intraocular pressure

KW - OCT

KW - UK Biobank

UR - http://www.scopus.com/inward/record.url?scp=85146634254&partnerID=8YFLogxK

U2 - 10.1016/j.ogla.2022.11.008

DO - 10.1016/j.ogla.2022.11.008

M3 - Article

C2 - 36481453

AN - SCOPUS:85146634254

SN - 2589-4234

VL - 6

SP - 366

EP - 379

JO - Ophthalmology. Glaucoma

JF - Ophthalmology. Glaucoma

IS - 4

ER -

Members of the International Glaucoma Genetics Consortium, Modifiable Risk Factors for Glaucoma Collaboration, the UK Biobank Eye and Vision Consortium, and the International Glaucoma Genetics Consortium, Members of the Modifiable Risk Factors for Glaucoma Collaboration, Members of the UK Biobank Eye and Vision Consortium, Stuart KV, Luben RN et al. The Association of Alcohol Consumption with Glaucoma and Related Traits: Findings from the UK Biobank. Ophthalmology. Glaucoma. 2023 Jul 1;6(4):366-379. doi: 10.1016/j.ogla.2022.11.008

The Association of Alcohol Consumption with Glaucoma and Related Traits: Findings from the UK Biobank

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this