The association between maternal cocaine use and placenta previa

G. A. Macones, H. M. Sehdev, S. Parry, M. A. Morgan, J. A. Berlin

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46 Scopus citations


OBJECTIVE: Our aim was to determine whether maternal cocaine exposure is a risk factor for placenta previa. STUDY DESIGN: In this case-control study, cases of placenta previa confirmed at delivery (ascertained by International Classification of Diseases, ninth revision. Clinical Modification, code- based search. N = 40) were compared with a random sample of patients without placenta previa (N = 80) in a ratio of two controls per case. Data on antecedent maternal cocaine use as well as other potential risk factors for placenta previa, were obtained from a review of the prenatal chart and the hospital record. Categorization of cocaine use was based on either patient self-report or urine toxicologic testing, or both. Multiple logistic regression was performed to assess me association between cocaine and placenta previa while we controlled for other variables. RESULTS: After the effects of other variables were adjusted for, maternal cocaine use was an independent risk factor for placenta previa (adjusted odds ratio = 4,39.95% confidence interval 1.17 to 16.4). Other significant risk factors included a history of cesarean section and prior elective abortion. CONCLUSION: These results suggest that cocaine use, as well as odor cesarean section, prior elective abortion, and parity, are associated with placenta previa.

Original languageEnglish
Pages (from-to)1097-1100
Number of pages4
JournalAmerican journal of obstetrics and gynecology
Issue number5
StatePublished - 1997


  • Abortion
  • Cesarean section
  • Cocaine use
  • Placenta previa


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