Aim: An association was recently reported between a low cesarean section delivery rate and a method of obstetrical care that involved the frequent use of risk-guided prostaglandin-assisted preventive labor induction. We sought to confirm this finding in a subsequent group of pregnant women. Methods: A retrospective cohort study design was used to compare the outcomes of 100 consecutively delivered women, who were exposed to the alternative method of care, with the outcomes of 300 randomly chosen women who received standard management. The primary outcome was group cesarean delivery rate. Secondary outcomes were rates of neonatal intensive care unit admission, low 1-minute Apgar score, low 5-minute Apgar score, and major perineal trauma. Results: Women exposed to the alternative method of obstetrical care had a higher induction rate (59% vs. 16.3%, p<0.001), a more frequent use of prostaglandins for cervical ripening (32% vs. 13%, p<0.001), and a lower cesarean delivery rate (7% vs. 20.3%, p=0.002). Exposed women did not experience higher rates of other adverse birth outcomes. Conclusions: Exposure to an alternative method of obstetrical care that used high levels of risk-driven prostaglandin-assisted labor was again associated with two findings: a lower group cesarean delivery rate and no increases in levels of other adverse birth outcomes. An adequately powered randomized controlled trial is needed to further explore this alternative method of care.