The Association Between Illness Severity Scores and In-hospital Mortality After Aneurysmal Subarachnoid Hemorrhage

Kornkamon Yuwapattanawong, Phuriphong Chanthima, Thanyalak Thamjamrassri, Jade Keen, Qian Qiu, Christine Fong, Ellen F. Robinson, Vasu B. Dhulipala, Andrew M. Walters, Umeshkumar Athiraman, Louis J. Kim, Monica S. Vavilala, Michael R. Levitt, Abhijit V. Lele

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: The purpose of this study was to examine the association with in-hospital mortality of 8 illness severity scores in patients with aneurysmal subarachnoid hemorrhage (aSAH). Methods: In a retrospective cohort study, we investigated the association with in-hospital mortality of admission Hunt and Hess (HH) score, Fisher grade, severity of illness and risk of mortality scores, and serial Glasgow coma scale (GCS) score in patients with aSAH. We also explored the changes in GCS between admission and discharge using a multivariate model adjusting for age, clinical vasospasm, and external ventricular drain status. Results: Data from 480 patients with aSAH, of which 383 (79.8%) aneurysms were in the anterior circulation, were included in analysis. Patients were female (n = 340, 70.8%) with a median age of 56 (interquartile range: 48 to 66) years. The majority (n = 332,69.2%) had admission HH score 3 to 5, Fisher grade 3 to 4 (n = 437, 91%), median severity of illness 3 (range: 1 to 4), median risk of mortality 3 (range: 1 to 4), and median admission GCS of 13 (interquartile range: 7 to 15). Overall, 406 (84.6%) patients received an external ventricular drain, 469 (97.7%) underwent aneurysm repair, and 60 died (12.5%). Compared with admission HH score, GCS 24 hours after admission (area under the curve: 0.84, 95% confidence interval [CI]: 0.79-0.88) and 24 hours after aneurysm repair (area under the curve: 0.87, 95% CI: 0.82-0.90) were more likely to be associated with in-hospital mortality. Among those who died, the greatest decline in GCS was noted between 24 hours after aneurysm repair and discharge (−3.38 points, 95% CI: –4.17, −2.58). Conclusions: Compared with admission HH score, GCS 24 hours after admission (or 24 h after aneurysm repair) is more likely to be associated with in-hospital mortality after aSAH.

Original languageEnglish
Pages (from-to)299-306
Number of pages8
JournalJournal of Neurosurgical Anesthesiology
Volume35
Issue number3
DOIs
StatePublished - 2023

Keywords

  • Glasgow coma scale
  • Hunt and Hess
  • admission
  • aneurysmal subarachnoid hemorrhage
  • mortality
  • scores
  • severity of illness

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