TY - JOUR
T1 - The association between cannabis abuse and dependence and childhood physical and sexual abuse
T2 - Evidence from an offspring of twins design
AU - Duncan, Alexis E.
AU - Sartor, Carolyn E.
AU - Scherrer, Jeffrey F.
AU - Grant, Julia D.
AU - Heath, Andrew C.
AU - Nelson, Elliot C.
AU - Jacob, Theodore
AU - Bucholz, Kathleen Keenan
PY - 2008/6
Y1 - 2008/6
N2 - Aim: This study examines the association between childhood physical abuse (CPA) and sexual abuse (CSA) and the development of cannabis abuse and dependence among adolescents and young adults while controlling for genetic and environmental risk factors. Design: To control for familial risk differences related to paternal drug dependence that might confound the relationship between CSA and CPA and cannabis abuse/dependence, we created four groups based on father's and uncle's substance use dependence (SUD) status reflecting different degrees of genetic and environmental risks to offspring: (i) high genetic, high environmental risk; (ii) high genetic, low environmental risk; (iii) medium genetic, low environmental risk; and (iv) low genetic, low environmental risk. Participants: Adolescent and young adult offspring of monozygotic and dizygotic US military veteran twin fathers (n = 819). Measurements: Data on CPA and CSA, DSM-IV offspring cannabis abuse/dependence, other SUD and psychopathology and maternal and paternal SUD and psychopathology were collected via semi-structured telephone interview. Findings: Twenty-three per cent of the offspring sample met life-time criteria for cannabis abuse/dependence and 8.55% and 12.82% reported CSA and CPA, respectively. Offspring exposed to CSA, but not CPA, were at significantly greater risk of developing cannabis abuse/dependence compared to those who had not experienced CSA (hazard ratio = 2.16; 95% confidence interval = 1.48-3.16) after controlling for genetic and familial environmental risk and offspring gender, alcohol abuse and dependence and conduct disorder. Conclusions: These results indicate that there are effects of CSA on development of cannabis abuse/dependence in addition to the genetic and familial environmental risk imparted by having a drug-dependent father.
AB - Aim: This study examines the association between childhood physical abuse (CPA) and sexual abuse (CSA) and the development of cannabis abuse and dependence among adolescents and young adults while controlling for genetic and environmental risk factors. Design: To control for familial risk differences related to paternal drug dependence that might confound the relationship between CSA and CPA and cannabis abuse/dependence, we created four groups based on father's and uncle's substance use dependence (SUD) status reflecting different degrees of genetic and environmental risks to offspring: (i) high genetic, high environmental risk; (ii) high genetic, low environmental risk; (iii) medium genetic, low environmental risk; and (iv) low genetic, low environmental risk. Participants: Adolescent and young adult offspring of monozygotic and dizygotic US military veteran twin fathers (n = 819). Measurements: Data on CPA and CSA, DSM-IV offspring cannabis abuse/dependence, other SUD and psychopathology and maternal and paternal SUD and psychopathology were collected via semi-structured telephone interview. Findings: Twenty-three per cent of the offspring sample met life-time criteria for cannabis abuse/dependence and 8.55% and 12.82% reported CSA and CPA, respectively. Offspring exposed to CSA, but not CPA, were at significantly greater risk of developing cannabis abuse/dependence compared to those who had not experienced CSA (hazard ratio = 2.16; 95% confidence interval = 1.48-3.16) after controlling for genetic and familial environmental risk and offspring gender, alcohol abuse and dependence and conduct disorder. Conclusions: These results indicate that there are effects of CSA on development of cannabis abuse/dependence in addition to the genetic and familial environmental risk imparted by having a drug-dependent father.
KW - Cannabis abuse
KW - Dependence
KW - Environmental risk factor
KW - Genes
KW - Offspring of twins
KW - Physical abuse
KW - Sexual abuse
UR - http://www.scopus.com/inward/record.url?scp=44149091043&partnerID=8YFLogxK
U2 - 10.1111/j.1360-0443.2008.02210.x
DO - 10.1111/j.1360-0443.2008.02210.x
M3 - Article
C2 - 18482422
AN - SCOPUS:44149091043
SN - 0965-2140
VL - 103
SP - 990
EP - 997
JO - Addiction
JF - Addiction
IS - 6
ER -