TY - JOUR
T1 - The Association Between C24:0/C16:0 Ceramide Ratio and Cardiorespiratory Fitness is Robust to Effect Modifications by Age and Sex
AU - Zatloukal, Jule
AU - Zylla, Stephanie
AU - Markus, Marcello R.P.
AU - Ewert, Ralf
AU - Gläser, Sven
AU - Völzke, Henry
AU - Albrecht, Diana
AU - Friedrich, Nele
AU - Nauck, Matthias
AU - Peterson, Linda R.
AU - Jiang, Xuntian
AU - Schaffer, Jean E.
AU - Felix, Stephan B.
AU - Dörr, Marcus
AU - Bahls, Martin
AU - Gross, Stefan
N1 - Publisher Copyright:
© 2024 The Authors. Advanced Biology published by Wiley-VCH GmbH.
PY - 2024/4
Y1 - 2024/4
N2 - Ceramides and cardiorespiratory (CR) fitness are both related to cardiovascular diseases. The associations of three blood plasma ceramides (C16:0, C22:0, and C24:0) with CR fitness in the population-based Study of Health in Pomerania (SHIP-START-1; n = 1,102; mean age 50.3 years, 51.5% women) are investigated. In addition, subgroup analysis according to age (</≥54 years) and sex (female/male) is performed. Ceramides are quantified by liquid chromatography/mass spectrometry (LC/MS). CR fitness is assessed by a cardiopulmonary exercise test. Sex and age independent associations are found for higher levels of C24:0 and C24:0/C16:0 ratio with higher maximal oxygen consumption (VO2peak) kg−1 and oxygen consumption at the anaerobic threshold (VO2@AT1) as well as for the relation of C24:0/C16:0 with maximum workload (Wattmax kg−1). In contrast, age/sex subgroup specific inverse associations with Wattmax kg−1 are found in women <54 years for C22:0, while a positive association in men ≥54 years. Higher levels of C24:0 are associated with higher Wattmax kg−1, except for women <54 years, where no significant association can be found. The findings suggest that the use of single ceramides as cardiovascular biomarkers may be inferior, compared to ceramide ratio C24:0/C16:0. Therefore C24:0/C16:0 ratio may be a more suitable and robust cardiovascular biomarker and should be preferred over single ceramides.
AB - Ceramides and cardiorespiratory (CR) fitness are both related to cardiovascular diseases. The associations of three blood plasma ceramides (C16:0, C22:0, and C24:0) with CR fitness in the population-based Study of Health in Pomerania (SHIP-START-1; n = 1,102; mean age 50.3 years, 51.5% women) are investigated. In addition, subgroup analysis according to age (</≥54 years) and sex (female/male) is performed. Ceramides are quantified by liquid chromatography/mass spectrometry (LC/MS). CR fitness is assessed by a cardiopulmonary exercise test. Sex and age independent associations are found for higher levels of C24:0 and C24:0/C16:0 ratio with higher maximal oxygen consumption (VO2peak) kg−1 and oxygen consumption at the anaerobic threshold (VO2@AT1) as well as for the relation of C24:0/C16:0 with maximum workload (Wattmax kg−1). In contrast, age/sex subgroup specific inverse associations with Wattmax kg−1 are found in women <54 years for C22:0, while a positive association in men ≥54 years. Higher levels of C24:0 are associated with higher Wattmax kg−1, except for women <54 years, where no significant association can be found. The findings suggest that the use of single ceramides as cardiovascular biomarkers may be inferior, compared to ceramide ratio C24:0/C16:0. Therefore C24:0/C16:0 ratio may be a more suitable and robust cardiovascular biomarker and should be preferred over single ceramides.
KW - cardiopulmonary exercise test
KW - cardiorespiratory fitness
KW - cardiovascular risk factors
KW - ceramides
UR - http://www.scopus.com/inward/record.url?scp=85184495154&partnerID=8YFLogxK
U2 - 10.1002/adbi.202300633
DO - 10.1002/adbi.202300633
M3 - Article
C2 - 38342586
AN - SCOPUS:85184495154
SN - 2701-0198
VL - 8
JO - Advanced Biology
JF - Advanced Biology
IS - 4
M1 - 2300633
ER -