TY - JOUR
T1 - The Arg16Gly Polymorphism of the β2-Adrenergic Receptor and Left Ventricular Systolic Function
AU - Tang, Weihong
AU - Devereux, Richard B.
AU - Kitzman, Dalane W.
AU - Province, Michael A.
AU - Leppert, Mark
AU - Oberman, Albert
AU - Hopkins, Paul N.
AU - Arnett, Donna K.
N1 - Funding Information:
The HyperGEN network is funded by the National Heart, Lung, and Blood Institute (NHLBI) R01 HL55673 and cooperative agreements (U10) with NHLBI: HL54471, HL54515 (UT), HL54472, HL54496 (MN), HL54473 (MO), HL54495 (AL), HL54509 (NC); Dr. Tang is supported by NHLBI training grant 1T32-HL07972-01.
PY - 2003/11
Y1 - 2003/11
N2 - Background: β-Adrenergic receptors (ARs), including β1- and β2-AR, are involved in modulation of cardiac contractility and heart rate. Arg16Gly, a functional polymorphism in the β2-AR gene, has been reported to influence exercise capacity in heart failure patients. This study examined the association of the β2-AR Arg16Gly polymorphism with left ventricular (LV) systolic function in a biethnic population-based sample. Methods: Echocardiograms and the β2-AR Arg16Gly polymorphism were analyzed in 267 normotensive (54% African Americans) and 252 severe hypertensive (53% African Americans) adults without coronary heart disease or diabetes. Results: The frequencies of Gly16Gly16, Arg16Gly16, and Arg16Arg16 were 28.1%, 54.3%, and 17.6%, respectively, in normotensives, and 31.4%, 47.6%, and 21.0%, respectively, in hypertensives. In normotensives, the Gly16Gly16 homozygotes displayed greater fractional shortening (35.9% ± 4.3% v 34.1% ± 4.7% v 34.0% ± 3.9%, P = .01), ejection fraction (65.0% ± 5.8% v 62.5% ± 6.4% v 62.6% ± 5.4%, P = .01), midwall shortening (18.6% ± 1.6% v 17.9% ± 1.9% v 18.0% ± 1.6%, P = .02), and stress-corrected midwall shortening (110.1% ± 9.3% v 106.1% ± 10.6% v 108.1% ± 10.8%, P = .03) compared to the Arg16Gly16 and Arg16Arg16 groups. These associations were independent of age, sex, ethnicity, heart rate, body mass index, systolic blood pressure, LV end-diastolic dimension, and field center. No significant associations between the β2-AR Arg16Gly polymorphism and echocardiographic measures were found in hypertensives. Conclusions: The Arg16Gly polymorphism of β2-AR may be a marker for LV chamber function and contractility in normotensive adults.
AB - Background: β-Adrenergic receptors (ARs), including β1- and β2-AR, are involved in modulation of cardiac contractility and heart rate. Arg16Gly, a functional polymorphism in the β2-AR gene, has been reported to influence exercise capacity in heart failure patients. This study examined the association of the β2-AR Arg16Gly polymorphism with left ventricular (LV) systolic function in a biethnic population-based sample. Methods: Echocardiograms and the β2-AR Arg16Gly polymorphism were analyzed in 267 normotensive (54% African Americans) and 252 severe hypertensive (53% African Americans) adults without coronary heart disease or diabetes. Results: The frequencies of Gly16Gly16, Arg16Gly16, and Arg16Arg16 were 28.1%, 54.3%, and 17.6%, respectively, in normotensives, and 31.4%, 47.6%, and 21.0%, respectively, in hypertensives. In normotensives, the Gly16Gly16 homozygotes displayed greater fractional shortening (35.9% ± 4.3% v 34.1% ± 4.7% v 34.0% ± 3.9%, P = .01), ejection fraction (65.0% ± 5.8% v 62.5% ± 6.4% v 62.6% ± 5.4%, P = .01), midwall shortening (18.6% ± 1.6% v 17.9% ± 1.9% v 18.0% ± 1.6%, P = .02), and stress-corrected midwall shortening (110.1% ± 9.3% v 106.1% ± 10.6% v 108.1% ± 10.8%, P = .03) compared to the Arg16Gly16 and Arg16Arg16 groups. These associations were independent of age, sex, ethnicity, heart rate, body mass index, systolic blood pressure, LV end-diastolic dimension, and field center. No significant associations between the β2-AR Arg16Gly polymorphism and echocardiographic measures were found in hypertensives. Conclusions: The Arg16Gly polymorphism of β2-AR may be a marker for LV chamber function and contractility in normotensive adults.
KW - Arg16Gly polymorphism
KW - Echocardiography
KW - Genetics
KW - Systolic function
KW - β2-adrenergic receptor
UR - http://www.scopus.com/inward/record.url?scp=0142200427&partnerID=8YFLogxK
U2 - 10.1016/S0895-7061(03)01001-X
DO - 10.1016/S0895-7061(03)01001-X
M3 - Article
C2 - 14573333
AN - SCOPUS:0142200427
SN - 0895-7061
VL - 16
SP - 945
EP - 951
JO - American Journal of Hypertension
JF - American Journal of Hypertension
IS - 11 I
ER -