The ARF/p53 pathway

Charles J. Sherr; Jason D. Weber

doi:10.1016/S0959-437X(99)00038-6

The ARF/p53 pathway

Charles J. Sherr
, Jason D. Weber

Research output: Contribution to journal › Review article › peer-review

592 Scopus citations

Abstract

The ARF tumor suppressor connects pathways regulated by the retinoblastoma protein and p53. ARF inactivation reduces p53-dependent apoptosis induced by oncogenic signals. Nucleolar relocalization of Mdm2 by ARF connotes a novel mechanism for preventing p53 turnover and provides a framework for understanding how stress signals cooperate to regulate p53 function.

Original language	English
Pages (from-to)	94-99
Number of pages	6
Journal	Current Opinion in Genetics and Development
Volume	10
Issue number	1
DOIs	https://doi.org/10.1016/S0959-437X(99)00038-6
State	Published - Feb 1 2000

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10.1016/S0959-437X(99)00038-6

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title = "The ARF/p53 pathway",

abstract = "The ARF tumor suppressor connects pathways regulated by the retinoblastoma protein and p53. ARF inactivation reduces p53-dependent apoptosis induced by oncogenic signals. Nucleolar relocalization of Mdm2 by ARF connotes a novel mechanism for preventing p53 turnover and provides a framework for understanding how stress signals cooperate to regulate p53 function.",

author = "Sherr, \{Charles J.\} and Weber, \{Jason D.\}",

note = "Funding Information: The authors thank Martine Roussel, James Roberts, Wade Harper, Galit Rotman, Tom Curran, and the other members of their laboratory for helpful criticisms of the manuscript. CJ Sherr is an Investigator and JD Weber is an Associate of the Howard Hughes Medical Institute. Both authors are also supported by American Lebanese Syrian Associated Charities (ALSAC) of St Jude Children{\textquoteright}s Research Hospital. ",

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doi = "10.1016/S0959-437X(99)00038-6",

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T1 - The ARF/p53 pathway

AU - Sherr, Charles J.

AU - Weber, Jason D.

N1 - Funding Information: The authors thank Martine Roussel, James Roberts, Wade Harper, Galit Rotman, Tom Curran, and the other members of their laboratory for helpful criticisms of the manuscript. CJ Sherr is an Investigator and JD Weber is an Associate of the Howard Hughes Medical Institute. Both authors are also supported by American Lebanese Syrian Associated Charities (ALSAC) of St Jude Children’s Research Hospital.

PY - 2000/2/1

Y1 - 2000/2/1

N2 - The ARF tumor suppressor connects pathways regulated by the retinoblastoma protein and p53. ARF inactivation reduces p53-dependent apoptosis induced by oncogenic signals. Nucleolar relocalization of Mdm2 by ARF connotes a novel mechanism for preventing p53 turnover and provides a framework for understanding how stress signals cooperate to regulate p53 function.

AB - The ARF tumor suppressor connects pathways regulated by the retinoblastoma protein and p53. ARF inactivation reduces p53-dependent apoptosis induced by oncogenic signals. Nucleolar relocalization of Mdm2 by ARF connotes a novel mechanism for preventing p53 turnover and provides a framework for understanding how stress signals cooperate to regulate p53 function.

UR - https://www.scopus.com/pages/publications/0033993563

U2 - 10.1016/S0959-437X(99)00038-6

DO - 10.1016/S0959-437X(99)00038-6

M3 - Review article

C2 - 10679383

AN - SCOPUS:0033993563

SN - 0959-437X

VL - 10

SP - 94

EP - 99

JO - Current Opinion in Genetics and Development

JF - Current Opinion in Genetics and Development

IS - 1

ER -

The ARF/p53 pathway

Abstract

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