The ARF tumor suppressor connects pathways regulated by the retinoblastoma protein and p53. ARF inactivation reduces p53-dependent apoptosis induced by oncogenic signals. Nucleolar relocalization of Mdm2 by ARF connotes a novel mechanism for preventing p53 turnover and provides a framework for understanding how stress signals cooperate to regulate p53 function.

Original languageEnglish
Pages (from-to)94-99
Number of pages6
JournalCurrent Opinion in Genetics and Development
Issue number1
StatePublished - Feb 1 2000


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