TY - JOUR
T1 - The application of positron emission tomography to the study of panic disorder
AU - Reiman, E. M.
AU - Raichle, M. E.
AU - Robins, E.
AU - Butler, F. K.
AU - Herscovitch, P.
AU - Fox, P.
AU - Perlmutter, J.
PY - 1986
Y1 - 1986
N2 - Positron emission tomography was used to study eight patients with panic disorder who were vulnerable to lactate-induced panic, eight patients with panic disorder who were not vulnerable to lactate-induced panic, and 25 normal control subjects. Patients who were vulnerable to lactate-induced panic had several abnormalities in the resting, nonpanic state: an abnormal hemispheric asymmetry of parahippocampal blood flow, blood volume, and oxygen metabolism; abnormally high whole brain metabolism; and abnormal susceptibility to episodic hyperventilation. A hypothetical model for the neurobiology of panic disorder, involving the abnormal parahippocampal region and its afferent and efferent connections is proposed.
AB - Positron emission tomography was used to study eight patients with panic disorder who were vulnerable to lactate-induced panic, eight patients with panic disorder who were not vulnerable to lactate-induced panic, and 25 normal control subjects. Patients who were vulnerable to lactate-induced panic had several abnormalities in the resting, nonpanic state: an abnormal hemispheric asymmetry of parahippocampal blood flow, blood volume, and oxygen metabolism; abnormally high whole brain metabolism; and abnormal susceptibility to episodic hyperventilation. A hypothetical model for the neurobiology of panic disorder, involving the abnormal parahippocampal region and its afferent and efferent connections is proposed.
UR - http://www.scopus.com/inward/record.url?scp=0022568740&partnerID=8YFLogxK
U2 - 10.1176/ajp.143.4.469
DO - 10.1176/ajp.143.4.469
M3 - Article
C2 - 3485385
AN - SCOPUS:0022568740
SN - 0002-953X
VL - 143
SP - 469
EP - 477
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
IS - 4
ER -