The AntiCD19 Antibody Drug Immunoconjugate Loncastuximab Achieves Responses in DLBCL Relapsing After AntiCD19 CAR-T Cell Therapy

Paolo F. Caimi, Kirit M. Ardeshna, Erin Reid, Weiyun Ai, Matthew Lunning, Jasmine Zain, Melhem Solh, Brad S. Kahl, Mehdi Hamadani

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Introduction: Chimeric antigen receptor T (CAR-T) cells targeting CD19 result in durable responses in approximately 40% of DLBCL patients. Loncastuximab tesirine, an antibody drug conjugate targeting CD19 with a pyrrolobenzodiazepine payload, has activity against DLBCL. Patients and Methods: We evaluated the outcomes of 13 DLBCL patients relapsed after CAR-T cells treated with loncastuximab in the LOTIS-2 trial. Results: Six patients (46%) had responses to loncastuximab (CR, n = 2). Median OS, PFS and duration of response after loncastuximab were 8.2, 1.4 and 8 months, respectively. Conclusion: Loncastuximab can achieve responses in patients progressing after CAR-T cells. Sequencing CD19-targeting therapies is possible in cases without CD19 loss.

Original languageEnglish
Pages (from-to)e335-e339
JournalClinical Lymphoma, Myeloma and Leukemia
Volume22
Issue number5
DOIs
StatePublished - May 2022

Keywords

  • CAR-T cell failures
  • Diffuse large B cell lymphoma

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