The anti-proteolytic behavior of lathyrogens

Judith Ann Foster, Celeste B. Rich, Nancy Berglund, Susan Huber, Robert P. Mecham, Gary Lange

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The lathyrogens, β-aminopropionitrile and α-aminoacetonitrile inhibit both the esterolytic and proteolytic activity of trypsin at a concentration of 100 mM. Lineweaver-Burk plots demonstrate that inhibition is competitive, with α-aminoacetonitrile being the more potent inhibitor. The enzyme associated with and capable of digesting tropoelastin is inhibited by both lathyrogens when tested against its natural substrate, tropoelastin. Administration of α-aminoacetonitrile-HCl to the diet of young chicks (0.1% w/w) resulted in a 62% increase in the yield of tropoelastin and significant reduction in fatality as compared to β-aminopropionitrile-fumerate.

Original languageEnglish
Pages (from-to)477-483
Number of pages7
JournalBBA - General Subjects
Issue number4
StatePublished - Nov 1 1979


  • Anti-proteolytic behaviorl
  • Competitive inhibition
  • Lathyrogen
  • Tropoelastin
  • α-Aminocetonitrile
  • β-Aminopropionnitrile

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