The Alzheimer's Biomarker Consortium-Down Syndrome: Rationale and methodology

the Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS)

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

Introduction: Adults with Down syndrome (DS) are at exceptionally high risk for Alzheimer's disease (AD), with virtually all individuals developing key neuropathological features by age 40. Identifying biomarkers of AD progression in DS can provide valuable insights into pathogenesis and suggest targets for disease modifying treatments. Methods: We describe the development of a multi-center, longitudinal study of biomarkers of AD in DS. The protocol includes longitudinal examination of clinical, cognitive, blood and cerebrospinal fluid-based biomarkers, magnetic resonance imaging and positron emission tomography measures (at 16-month intervals), as well as genetic modifiers of AD risk and progression. Results: Approximately 400 individuals will be enrolled in the study (more than 370 to date). The methodological approach from the administrative, clinical, neuroimaging, omics, neuropathology, and statistical cores is provided. Discussion: This represents the largest U.S.-based, multi-site, biomarker initiative of AD in DS. Findings can inform other multidisciplinary networks studying AD in the general population.

Original languageEnglish
Article numbere12065
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume12
Issue number1
DOIs
StatePublished - 2020

Keywords

  • ABC-DS
  • Alzheimer's disease
  • Down syndrome
  • dementia

Fingerprint

Dive into the research topics of 'The Alzheimer's Biomarker Consortium-Down Syndrome: Rationale and methodology'. Together they form a unique fingerprint.

Cite this