The activation of lytic replication of Epstein-Barr virus by baculovirus-mediated gene transduction

L. Wang; L. Shan; J. Yin; M. Zhao; D. Su; J. Zhong

doi:10.1007/s00705-006-0772-5

The activation of lytic replication of Epstein-Barr virus by baculovirus-mediated gene transduction

L. Wang
, L. Shan
, J. Yin
, M. Zhao
, D. Su
, J. Zhong

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

A baculoviral mammalian-cell vector was constructed to express Rta, a protein of Epstein-Barr virus (EBV) responsible for the transition from latent infection to lytic replication. EBV lytic replication and cell-growth inhibition was observed in infected D98/HR1 cells. The baculovirus caused little cytotoxicity in the non-targeted HeLa cells, compared to an adenovirus vector. It is concluded that recombinant baculovirus might have the potential as a vector for the therapy of EBV-related cancer.

Original language	English
Pages (from-to)	2047-2053
Number of pages	7
Journal	Handbook of Environmental Chemistry, Volume 5: Water Pollution
Volume	151
Issue number	10
DOIs	https://doi.org/10.1007/s00705-006-0772-5
State	Published - Oct 2006

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abstract = "A baculoviral mammalian-cell vector was constructed to express Rta, a protein of Epstein-Barr virus (EBV) responsible for the transition from latent infection to lytic replication. EBV lytic replication and cell-growth inhibition was observed in infected D98/HR1 cells. The baculovirus caused little cytotoxicity in the non-targeted HeLa cells, compared to an adenovirus vector. It is concluded that recombinant baculovirus might have the potential as a vector for the therapy of EBV-related cancer.",

author = "L. Wang and L. Shan and J. Yin and M. Zhao and D. Su and J. Zhong",

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AU - Shan, L.

AU - Yin, J.

AU - Zhao, M.

AU - Su, D.

AU - Zhong, J.

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AB - A baculoviral mammalian-cell vector was constructed to express Rta, a protein of Epstein-Barr virus (EBV) responsible for the transition from latent infection to lytic replication. EBV lytic replication and cell-growth inhibition was observed in infected D98/HR1 cells. The baculovirus caused little cytotoxicity in the non-targeted HeLa cells, compared to an adenovirus vector. It is concluded that recombinant baculovirus might have the potential as a vector for the therapy of EBV-related cancer.

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U2 - 10.1007/s00705-006-0772-5

DO - 10.1007/s00705-006-0772-5

M3 - Article

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JO - Handbook of Environmental Chemistry, Volume 5: Water Pollution

JF - Handbook of Environmental Chemistry, Volume 5: Water Pollution

IS - 10

ER -

The activation of lytic replication of Epstein-Barr virus by baculovirus-mediated gene transduction

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