The abdominal region of the bithorax complex

François Karch, Barbara Weiffenbach, Mark Peifer, Welcome Bender, Ian Duncan, Susan Celniker, Madeline Crosby, E. B. Lewis

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


The homeotic mutations in the right half of the bithorax complex of Drosophila cause segmental transformations in the second through the eighth segments of the fly. A chromosomal walk in the bithorax complex has now been extended 215 kb through the right half of the complex, and lesions for over 40 mutations have been located on the DNA map. The mutations can be grouped in a series of phenotypic classes, one for each abdominal segment, although each mutation typically affects more than one segment. The mutant lesions of each class are clustered, and they are aligned on the chromosome in the order of the body segments that they affect. Complementation tests suggest interactions between widely spaced DNA regions; indeed, the right half cannot be split anywhere without some loss of function.

Original languageEnglish
Title of host publicationGenes, Development, and Cancer
Subtitle of host publicationThe Life and Work of Edward B. Lewis
PublisherSpringer Netherlands
Number of pages31
ISBN (Print)9781402063435
StatePublished - 2007


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