The β5-loop and lid domain contribute to the substrate specificity of pancreatic lipase-related protein 2 (PNLIPRP2)

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Abstract

Background: Two pancreatic lipases differ in substrate specificities. Results: Substitution of specific surface loops from one lipase into the other decreases activity against triglycerides and galactolipids. Conclusion: The β5-loop and lid domain influence lipase substrate specificity. Significance: Defining the relationship of structure to lipase function is crucial for understanding lipolysis and developing reagents to modulate lipase activity.

Original languageEnglish
Pages (from-to)28847-28856
Number of pages10
JournalJournal of Biological Chemistry
Volume290
Issue number48
DOIs
StatePublished - Nov 27 2015
Externally publishedYes

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