Thalamocortical model for a propofol-induced α-rhythm associated with loss of consciousness

Shinung Ching; Aylin Cimenser; Patrick L. Purdon; Emery N. Brown; Nancy J. Kopell

doi:10.1073/pnas.1017069108

Thalamocortical model for a propofol-induced α-rhythm associated with loss of consciousness

Shinung Ching, Aylin Cimenser, Patrick L. Purdon, Emery N. Brown, Nancy J. Kopell

Research output: Contribution to journal › Article › peer-review

292 Scopus citations

Abstract

Recent data reveal that the general anesthetic propofol gives rise to a frontal α-rhythm at dose levels sufficient to induce loss of consciousness. In this work, a computational model is developed that suggests the network mechanisms responsible for such a rhythm. It is shown that propofol can alter the dynamics in thalamocortical loops, leading to persistent and synchronous α-activity. The synchrony that forms in the cortex by virtue of the involvement of the thalamus may impede responsiveness to external stimuli, thus providing a correlate for the unconscious state.

Original language	English
Pages (from-to)	22665-22670
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	107
Issue number	52
DOIs	https://doi.org/10.1073/pnas.1017069108
State	Published - Dec 28 2010

Keywords

GABA
General anesthesia
Global coherence
Oscillations

Access to Document

10.1073/pnas.1017069108

Cite this

@article{fcba91ee72ce4c718d485d3f8ffe98aa,

title = "Thalamocortical model for a propofol-induced α-rhythm associated with loss of consciousness",

abstract = "Recent data reveal that the general anesthetic propofol gives rise to a frontal α-rhythm at dose levels sufficient to induce loss of consciousness. In this work, a computational model is developed that suggests the network mechanisms responsible for such a rhythm. It is shown that propofol can alter the dynamics in thalamocortical loops, leading to persistent and synchronous α-activity. The synchrony that forms in the cortex by virtue of the involvement of the thalamus may impede responsiveness to external stimuli, thus providing a correlate for the unconscious state.",

keywords = "GABA, General anesthesia, Global coherence, Oscillations",

author = "Shinung Ching and Aylin Cimenser and Purdon, {Patrick L.} and Brown, {Emery N.} and Kopell, {Nancy J.}",

year = "2010",

month = dec,

day = "28",

doi = "10.1073/pnas.1017069108",

language = "English",

volume = "107",

pages = "22665--22670",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

number = "52",

}

TY - JOUR

T1 - Thalamocortical model for a propofol-induced α-rhythm associated with loss of consciousness

AU - Ching, Shinung

AU - Cimenser, Aylin

AU - Purdon, Patrick L.

AU - Brown, Emery N.

AU - Kopell, Nancy J.

PY - 2010/12/28

Y1 - 2010/12/28

N2 - Recent data reveal that the general anesthetic propofol gives rise to a frontal α-rhythm at dose levels sufficient to induce loss of consciousness. In this work, a computational model is developed that suggests the network mechanisms responsible for such a rhythm. It is shown that propofol can alter the dynamics in thalamocortical loops, leading to persistent and synchronous α-activity. The synchrony that forms in the cortex by virtue of the involvement of the thalamus may impede responsiveness to external stimuli, thus providing a correlate for the unconscious state.

AB - Recent data reveal that the general anesthetic propofol gives rise to a frontal α-rhythm at dose levels sufficient to induce loss of consciousness. In this work, a computational model is developed that suggests the network mechanisms responsible for such a rhythm. It is shown that propofol can alter the dynamics in thalamocortical loops, leading to persistent and synchronous α-activity. The synchrony that forms in the cortex by virtue of the involvement of the thalamus may impede responsiveness to external stimuli, thus providing a correlate for the unconscious state.

KW - GABA

KW - General anesthesia

KW - Global coherence

KW - Oscillations

UR - http://www.scopus.com/inward/record.url?scp=78651112737&partnerID=8YFLogxK

U2 - 10.1073/pnas.1017069108

DO - 10.1073/pnas.1017069108

M3 - Article

C2 - 21149695

AN - SCOPUS:78651112737

SN - 0027-8424

VL - 107

SP - 22665

EP - 22670

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 52

ER -

Thalamocortical model for a propofol-induced α-rhythm associated with loss of consciousness

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this