Th17 cytokines and vaccine-induced immunity

Yinyao Lin; Samantha R. Slight; Shabaana A. Khader

doi:10.1007/s00281-009-0191-2

Th17 cytokines and vaccine-induced immunity

Yinyao Lin, Samantha R. Slight, Shabaana A. Khader

Research output: Contribution to journal › Review article › peer-review

110 Scopus citations

Abstract

T helper type 17 (Th17) cells are a distinct lineage of T cells that produce the effector molecules IL-17, IL-17F, IL-21, and IL-22. Although the role of Th17 cells in primary immune responses against infections is well documented, there is growing evidence that the Th17 lineage maybe critical for vaccine-induced memory immune responses against infectious diseases. Here, we summarize recent progress in our understanding of the role of IL-17 in vaccine-induced immunity.

Original language	English
Pages (from-to)	79-90
Number of pages	12
Journal	Seminars in Immunopathology
Volume	32
Issue number	1
DOIs	https://doi.org/10.1007/s00281-009-0191-2
State	Published - Mar 2010

Keywords

Infection
Th17
Vaccine-induced immunity

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10.1007/s00281-009-0191-2

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title = "Th17 cytokines and vaccine-induced immunity",

abstract = "T helper type 17 (Th17) cells are a distinct lineage of T cells that produce the effector molecules IL-17, IL-17F, IL-21, and IL-22. Although the role of Th17 cells in primary immune responses against infections is well documented, there is growing evidence that the Th17 lineage maybe critical for vaccine-induced memory immune responses against infectious diseases. Here, we summarize recent progress in our understanding of the role of IL-17 in vaccine-induced immunity.",

keywords = "Infection, Th17, Vaccine-induced immunity",

author = "Yinyao Lin and Slight, {Samantha R.} and Khader, {Shabaana A.}",

note = "Funding Information: This work was supported by Children{\textquoteright}s Hospital Of Pittsburgh, Pennsylvania Department of Health Formula Funding, AI075106, A1083541 from National Institute of Health, USA to SAK. The authors thank Dr. Sarah Gaffen, University of Pittsburgh School of Medicine for critical reading of the manuscript. The authors have no conflicting financial interests.",

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AU - Slight, Samantha R.

AU - Khader, Shabaana A.

N1 - Funding Information: This work was supported by Children’s Hospital Of Pittsburgh, Pennsylvania Department of Health Formula Funding, AI075106, A1083541 from National Institute of Health, USA to SAK. The authors thank Dr. Sarah Gaffen, University of Pittsburgh School of Medicine for critical reading of the manuscript. The authors have no conflicting financial interests.

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N2 - T helper type 17 (Th17) cells are a distinct lineage of T cells that produce the effector molecules IL-17, IL-17F, IL-21, and IL-22. Although the role of Th17 cells in primary immune responses against infections is well documented, there is growing evidence that the Th17 lineage maybe critical for vaccine-induced memory immune responses against infectious diseases. Here, we summarize recent progress in our understanding of the role of IL-17 in vaccine-induced immunity.

AB - T helper type 17 (Th17) cells are a distinct lineage of T cells that produce the effector molecules IL-17, IL-17F, IL-21, and IL-22. Although the role of Th17 cells in primary immune responses against infections is well documented, there is growing evidence that the Th17 lineage maybe critical for vaccine-induced memory immune responses against infectious diseases. Here, we summarize recent progress in our understanding of the role of IL-17 in vaccine-induced immunity.

KW - Infection

KW - Th17

KW - Vaccine-induced immunity

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M3 - Review article

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AN - SCOPUS:77949654682

SN - 1863-2297

VL - 32

SP - 79

EP - 90

JO - Seminars in Immunopathology

JF - Seminars in Immunopathology

IS - 1

ER -

Th17 cytokines and vaccine-induced immunity

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Keywords

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