Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa

S. A. Khader, S. L. Gaffen, J. K. Kolls

Research output: Contribution to journalReview articlepeer-review

316 Scopus citations

Abstract

T helper type 17 (Th17) cells are a distinct lineage of T cells that produce the effector molecules IL-17, IL-17F, IL-21, and IL-22. Although the role of Th17 cells in autoimmunity is well documented, there is growing evidence that the Th17 lineage and other interleukin (IL)-17-producing cells are critical for host defense against bacterial, fungal, and viral infections at mucosal surfaces. Here we summarize recent progress in our understanding of the function of IL-17-producing cells as a bridge between innate and adaptive immunity against infectious diseases at the mucosa.

Original languageEnglish
Pages (from-to)403-411
Number of pages9
JournalMucosal Immunology
Volume2
Issue number5
DOIs
StatePublished - 2009

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