TY - JOUR
T1 - Th17
T2 - An Effector CD4 T Cell Lineage with Regulatory T Cell Ties
AU - Weaver, Casey T.
AU - Harrington, Laurie E.
AU - Mangan, Paul R.
AU - Gavrieli, Maya
AU - Murphy, Kenneth M.
N1 - Funding Information:
The authors thank members of the Weaver and Murphy labs for helpful comments and suggestions. We also thank Noelle LeLievre for editorial assistance. We offer our apologies to colleagues whose work could not be adequately cited or discussed due to space limitations. This work was supported by the NIH (grants AI35783, AI57956, and DK64400 to C.T.W.), Sankyo Co. Ltd. (C.T.W.), and the Howard Hughes Medical Institute (K.M.M.).
PY - 2006/6
Y1 - 2006/6
N2 - The naive CD4 T cell is a multipotential precursor with defined antigen recognition specificity but substantial plasticity for development down distinct effector or regulatory lineages, contingent upon signals from cells of the innate immune system. The range of identified effector CD4 T cell lineages has recently expanded with description of an IL-17-producing subset, called Th17, which develops via cytokine signals distinct from, and antagonized by, products of the Th1 and Th2 lineages. Remarkably, Th17 development depends on the pleiotropic cytokine TGF-β, which is also linked to regulatory T cell development and function, providing a unique mechanism for matching CD4 T cell effector and regulatory lineage specification. Here, we review Th17 lineage development, emphasizing similarities and differences with established effector and regulatory T cell developmental programs that have important implications for immune regulation, immune pathogenesis, and host defense.
AB - The naive CD4 T cell is a multipotential precursor with defined antigen recognition specificity but substantial plasticity for development down distinct effector or regulatory lineages, contingent upon signals from cells of the innate immune system. The range of identified effector CD4 T cell lineages has recently expanded with description of an IL-17-producing subset, called Th17, which develops via cytokine signals distinct from, and antagonized by, products of the Th1 and Th2 lineages. Remarkably, Th17 development depends on the pleiotropic cytokine TGF-β, which is also linked to regulatory T cell development and function, providing a unique mechanism for matching CD4 T cell effector and regulatory lineage specification. Here, we review Th17 lineage development, emphasizing similarities and differences with established effector and regulatory T cell developmental programs that have important implications for immune regulation, immune pathogenesis, and host defense.
UR - http://www.scopus.com/inward/record.url?scp=33744984785&partnerID=8YFLogxK
U2 - 10.1016/j.immuni.2006.06.002
DO - 10.1016/j.immuni.2006.06.002
M3 - Review article
C2 - 16782025
AN - SCOPUS:33744984785
SN - 1074-7613
VL - 24
SP - 677
EP - 688
JO - Immunity
JF - Immunity
IS - 6
ER -