TGF-β1 gene-race interactions for resting and exercise blood pressure in the HERITAGE family study

Miguel A. Rivera, Marcos Echegaray, Tuomo Rankinen, Louis Pérusse, Treva Rice, Jacques Gagnon, Arthur S. Leon, James S. Skinner, Jack H. Wilmore, D. C. Rao, Claude Bouchard

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We examined the possible association between a transforming growth factor (TGF)-β1 gene polymorphism in codon 10 and blood pressure (BP) at rest, in acute response to exercise in the pretrained (sedentary) and trained states, as well as in its training response (Δ) to 20 wk of endurance exercise. Subjects were 257 black and 480 white, healthy sedentary normotensive subjects from the HERITAGE Family Study. The polymorphism was detected by polymerase chain reaction and digestion with the Msp A1 I endonuclease yielding a wild (leucine-10) and a mutant (proline-10) allele. Resting and exercise [50 W plus 60, 80, and 100% maximal oxygen consumption (VO2 max)] BP were determined before and after training. Significant (P < 0.05) race-genotype interactions were found for systolic (S) BP in both the sedentary and trained states. Among whites but not in blacks, the TGF-β1 genotypes were significantly (P < 0.05) associated with sedentary-state SBP at rest, at 50 W, and at 60 and 100% VO2 max as well as with trained-state SBP at rest and at 80 and 100% VO2 max. The leucine-10 homozygotes had significantly (P < 0.05) lower SBP than proline-10 homozygotes. ΔBP was not significantly associated with genotype. These results support the hypothesis of an association between the TGF-β1 marker in codon 10 and SBP at rest and in response to acute exercise in whites but not in blacks.

Original languageEnglish
Pages (from-to)1808-1813
Number of pages6
JournalJournal of Applied Physiology
Issue number4
StatePublished - 2001


  • DNA
  • Endurance
  • Genetic variation
  • Genetics
  • Polymerase chain reaction
  • Transforming growth factor-β


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