TGF-β signaling plays an essential role in the growth and maintenance of intervertebral disc tissue

Hongting Jin, Jie Shen, Baoli Wang, Meina Wang, Bing Shu, Di Chen

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

TGF-β signaling plays a critical role in cartilage and spine tissue development at embryonic stage but its role in postnatal intervertebral disc (IVD) tissue growth and maintenance remain poorly understood. In the present studies, we have deleted the Tgfbr2 gene in inner annulus fibrosus cells of the disc tissue and surrounding growth plate chondrocytes using Col2a1-CreER T2 transgenic mice. We found that TGF-β signaling is required for normal growth plate cartilage and endplate cartilage growth at postnatal stage. The expression of Mmp13 gene is significantly up-regulated in primary disc cells of Tgfbr2 conditional knockout mice. Deletion of the Mmp13 gene under Tgfbr2 null background completely reverses the abnormal disc phenotype found in Tgfbr2 knockout mice.

Original languageEnglish
Pages (from-to)1209-1215
Number of pages7
JournalFEBS Letters
Volume585
Issue number8
DOIs
StatePublished - Apr 20 2011
Externally publishedYes

Keywords

  • Col2a1-CreER
  • Conditional knockout
  • Intervertebral disc
  • MMP-13
  • TGF-β

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