TGF-β signaling and the development of osteoarthritis

Jie Shen, Shan Li, Di Chen

Research output: Contribution to journalReview article

120 Scopus citations

Abstract

Osteoarthritis (OA) is a common joint degenerative disease affecting the whole joint structure, including articular cartilage, subchondral bone and synovial tissue. Although extensive work has been done in recent years to explore the molecular mechanism underlying this disease, the pathogenesis of OA is still poorly understood and currently, there is no effective disease-modifying treatment for OA. Recently, both in vitro and in vivo studies suggest that confirmed (TGF-β)/SMAD pathway plays a critical role during OA development. This short review will focus on the function and signaling mechanisms of TGF-β/SMAD pathway in articular chondrocytes, mesenchymal progenitor cells of subchondral bone and synovial lining cells during OA development.

Original languageEnglish
Article number14002
JournalBone Research
Volume2
DOIs
StatePublished - May 27 2014
Externally publishedYes

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