TY - JOUR
T1 - TGF-β signaling and the development of osteoarthritis
AU - Shen, Jie
AU - Li, Shan
AU - Chen, Di
N1 - Funding Information:
This work was supported by Grants R01 AR055915 and R01 AR054465 to DC from the National Institute of Health. The authors thank Verhonda Hearon-Eggleston for her assistance in preparing the manuscript.
Publisher Copyright:
© 2014 Sichuan University All rights reserved.
PY - 2014/5/27
Y1 - 2014/5/27
N2 - Osteoarthritis (OA) is a common joint degenerative disease affecting the whole joint structure, including articular cartilage, subchondral bone and synovial tissue. Although extensive work has been done in recent years to explore the molecular mechanism underlying this disease, the pathogenesis of OA is still poorly understood and currently, there is no effective disease-modifying treatment for OA. Recently, both in vitro and in vivo studies suggest that confirmed (TGF-β)/SMAD pathway plays a critical role during OA development. This short review will focus on the function and signaling mechanisms of TGF-β/SMAD pathway in articular chondrocytes, mesenchymal progenitor cells of subchondral bone and synovial lining cells during OA development.
AB - Osteoarthritis (OA) is a common joint degenerative disease affecting the whole joint structure, including articular cartilage, subchondral bone and synovial tissue. Although extensive work has been done in recent years to explore the molecular mechanism underlying this disease, the pathogenesis of OA is still poorly understood and currently, there is no effective disease-modifying treatment for OA. Recently, both in vitro and in vivo studies suggest that confirmed (TGF-β)/SMAD pathway plays a critical role during OA development. This short review will focus on the function and signaling mechanisms of TGF-β/SMAD pathway in articular chondrocytes, mesenchymal progenitor cells of subchondral bone and synovial lining cells during OA development.
UR - http://www.scopus.com/inward/record.url?scp=84922199194&partnerID=8YFLogxK
U2 - 10.1038/boneres.2014.2
DO - 10.1038/boneres.2014.2
M3 - Review article
C2 - 25541594
AN - SCOPUS:84922199194
SN - 2095-4700
VL - 2
JO - Bone Research
JF - Bone Research
M1 - 14002
ER -