Textural kinetics: A novel dynamic contrast-enhanced (DCE)-MRI feature for breast lesion classification

Shannon C. Agner, Salil Soman, Edward Libfeld, Margie McDonald, Kathleen Thomas, Sarah Englander, Mark A. Rosen, Deanna Chin, John Nosher, Anant Madabhushi

Research output: Contribution to journalArticlepeer-review

92 Scopus citations

Abstract

Dynamic contrast-enhanced (DCE)-magnetic resonance imaging (MRI) of the breast has emerged as an adjunct imaging tool to conventional X-ray mammography due to its high detection sensitivity. Despite the increasing use of breast DCE-MRI, specificity in distinguishing malignant from benign breast lesions is low, and interobserver variability in lesion classification is high. The novel contribution of this paper is in the definition of a new DCE-MRI descriptor that we call textural kinetics, which attempts to capture spatiotemporal changes in breast lesion texture in order to distinguish malignant from benign lesions. We qualitatively and quantitatively demonstrated on 41 breast DCE-MRI studies that textural kinetic features outperform signal intensity kinetics and lesion morphology features in distinguishing benign from malignant lesions. A probabilistic boosting tree (PBT) classifier in conjunction with textural kinetic descriptors yielded an accuracy of 90%, sensitivity of 95%, specificity of 82%, and an area under the curve (AUC) of 0.92. Graph embedding, used for qualitative visualization of a low-dimensional representation of the data, showed the best separation between benign and malignant lesions when using textural kinetic features. The PBT classifier results and trends were also corroborated via a support vector machine classifier which showed that textural kinetic features outperformed the morphological, static texture, and signal intensity kinetics descriptors. When textural kinetic attributes were combined with morphologic descriptors, the resulting PBT classifier yielded 89% accuracy, 99% sensitivity, 76% specificity, and an AUC of 0.91.

Original languageEnglish
Pages (from-to)446-463
Number of pages18
JournalJournal of Digital Imaging
Volume24
Issue number3
DOIs
StatePublished - Jun 2011

Keywords

  • Breast cancer
  • CAD
  • Cancer imaging
  • Classifier
  • DCE-MRI
  • Diagnosis
  • Feature
  • MRI
  • Probabilistic boosting tree
  • Support vector machine
  • Textural kinetics
  • Texture
  • Tumor

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