Text-mining assisted regulatory annotation

Stein Aerts, Maximilian Haeussler, Steven van Vooren, Obi L. Griffith, Paco Hulpiau, Steven J.M. Jones, Stephen B. Montgomery, Casey M. Bergman

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Background: Decoding transcriptional regulatory networks and the genomic cis-regulatory logic implemented in their control nodes is a fundamental challenge in genome biology. High-throughput computational and experimental analyses of regulatory networks and sequences rely heavily on positive control data from prior small-scale experiments, but the vast majority of previously discovered regulatory data remains locked in the biomedical literature. Results: We develop text-mining strategies to identify relevant publications and extract sequence information to assist the regulatory annotation process. Using a vector space model to identify Medline abstracts from papers likely to have high cis-regulatory content, we demonstrate that document relevance ranking can assist the curation of transcriptional regulatory networks and estimate that, minimally, 30,000 papers harbor unannotated cis-regulatory data. In addition, we show that DNA sequences can be extracted from primary text with high cis-regulatory content and mapped to genome sequences as a means of identifying the location, organism and target gene information that is critical to the cis-regulatory annotation process. Conclusion: Our results demonstrate that text-mining technologies can be successfully integrated with genome annotation systems, thereby increasing the availability of annotated cis-regulatory data needed to catalyze advances in the field of gene regulation.

Original languageEnglish
Article numberR31
JournalGenome biology
Volume9
Issue number2
DOIs
StatePublished - Feb 13 2008

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