Testing the Amyloid Hypothesis with a Humanized AD Mouse Model

Michelle K. Cahill; Eric J. Huang

doi:10.1016/j.neuron.2017.02.044

Testing the Amyloid Hypothesis with a Humanized AD Mouse Model

Michelle K. Cahill, Eric J. Huang

Research output: Contribution to journal › Short survey › peer-review

9 Scopus citations

Abstract

In this issue of Neuron, Espuny-Camacho et al. (2017) generate a humanized Alzheimer's disease (AD) model that reveals species-specific vulnerability of human neurons to AD pathology. This model provides key insights for disease mechanism and therapeutic discovery for AD.

Original language	English
Pages (from-to)	987-989
Number of pages	3
Journal	Neuron
Volume	93
Issue number	5
DOIs	https://doi.org/10.1016/j.neuron.2017.02.044
State	Published - Mar 8 2017

Keywords

Alzheimer's disease
amyloid plaque
induced pluripotent stem cells (iPSCs)
mouse model
neurofibrillary tangle
transplantation

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10.1016/j.neuron.2017.02.044

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title = "Testing the Amyloid Hypothesis with a Humanized AD Mouse Model",

abstract = "In this issue of Neuron, Espuny-Camacho et al. (2017) generate a humanized Alzheimer's disease (AD) model that reveals species-specific vulnerability of human neurons to AD pathology. This model provides key insights for disease mechanism and therapeutic discovery for AD.",

keywords = "Alzheimer's disease, amyloid plaque, induced pluripotent stem cells (iPSCs), mouse model, neurofibrillary tangle, transplantation",

author = "Cahill, {Michelle K.} and Huang, {Eric J.}",

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AB - In this issue of Neuron, Espuny-Camacho et al. (2017) generate a humanized Alzheimer's disease (AD) model that reveals species-specific vulnerability of human neurons to AD pathology. This model provides key insights for disease mechanism and therapeutic discovery for AD.

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KW - amyloid plaque

KW - induced pluripotent stem cells (iPSCs)

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KW - neurofibrillary tangle

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JO - Neuron

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Testing the Amyloid Hypothesis with a Humanized AD Mouse Model

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Keywords

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