Testicular circulatory isolation: a Phase I study

J. J. Gibbons, R. O. Parra, G. L. Andriole, F. E. Johnson

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Antineoplastic agents may damage germinal epithelium. Testicular circulatory isolation (TCI) is a regional drug exclusion technique designed to minimize this. We evaluated the technical and anaesthetic aspects of TCI in 10 patients who underwent bilateral orchiectomy immediately thereafter. A modified aortic clamp was placed trans-scrotally across the left testicular pedicle without pre-medication or anaesthesia and left in place for 1 h, occluding testicular blood flow. Minimal pain and anxiety were reported during the procedure. There were no complications related to TCI in any patient. This study supports the institution of trials of TCI in young men about to receive fertility-threatening chemotherapy.

Original languageEnglish
Pages (from-to)413-416
Number of pages4
JournalSurgical Oncology
Issue number6
StatePublished - Dec 1992


  • drug toxicity
  • infertility
  • regional drug delivery
  • testicle


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