TY - JOUR
T1 - Test-retest reproducibility of optic disk deterioration detected from stereophotographs by masked graders
AU - Parrish, Richard K.
AU - Schiffman, Joyce C.
AU - Feuer, William J.
AU - Anderson, Douglas R.
AU - Budenz, Donald L.
AU - Wells-Albornoz, Maria Cristina
AU - Vandenbroucke, Ruth
AU - Kass, Michael A.
AU - Gordon, Mae O.
PY - 2005/10
Y1 - 2005/10
N2 - PURPOSE: To assess the reproducibility of determining whether an eye has developed optic disk deterioration by the Optic Disc Reading Center (ODRC) in the Ocular Hypertension Treatment Study (OHTS). DESIGN: Test-retest reproducibility study. METHODS: Masked, certified graders at the ODRC determine the occurrence of optic disk deterioration in OHTS by comparing baseline with follow-up stereoscopic optic disk photographs. To assess reproducibility, regradings were obtained annually by inserting masked "quality control" photographs into the usual ODRC reading stream. RESULTS: Agreement (kappa) ranged from 0.65 to 0.83 over 5 years. Specificity ranged from 98% to 100%, and sensitivity ranged from 64% to 81%. CONCLUSIONS: The kappa statistic for test-retest agreement in OHTS is in the range considered good to excellent over 5 years. Consistency (specificity) in regrading optic disks that did not develop deterioration was particularly high. The sensitivity results show that detecting subtle deterioration of optic disks is challenging.
AB - PURPOSE: To assess the reproducibility of determining whether an eye has developed optic disk deterioration by the Optic Disc Reading Center (ODRC) in the Ocular Hypertension Treatment Study (OHTS). DESIGN: Test-retest reproducibility study. METHODS: Masked, certified graders at the ODRC determine the occurrence of optic disk deterioration in OHTS by comparing baseline with follow-up stereoscopic optic disk photographs. To assess reproducibility, regradings were obtained annually by inserting masked "quality control" photographs into the usual ODRC reading stream. RESULTS: Agreement (kappa) ranged from 0.65 to 0.83 over 5 years. Specificity ranged from 98% to 100%, and sensitivity ranged from 64% to 81%. CONCLUSIONS: The kappa statistic for test-retest agreement in OHTS is in the range considered good to excellent over 5 years. Consistency (specificity) in regrading optic disks that did not develop deterioration was particularly high. The sensitivity results show that detecting subtle deterioration of optic disks is challenging.
UR - http://www.scopus.com/inward/record.url?scp=26844520871&partnerID=8YFLogxK
U2 - 10.1016/j.ajo.2005.04.044
DO - 10.1016/j.ajo.2005.04.044
M3 - Article
C2 - 16226544
AN - SCOPUS:26844520871
SN - 0002-9394
VL - 140
SP - 762
EP - 764
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 4
ER -