TY - JOUR
T1 - Teratologic effects of ethylnitrosourea on brain development in rats
AU - Pfaffenroth, Michael J.
AU - Das, Gopal D.
AU - McAllister, James P.
PY - 1974/6
Y1 - 1974/6
N2 - Wistar rats were injected iv with ethlnitrosourea (ENU) between days 14 and 21 of gestation and the offspring killed 0, 3, 6, 10, 15, 21, and 75 days after birth. The brains obtained from these animals, on macroscopic examination, revealed that ENU produced micrencephaly of variable degrees reflected predominantly in the reduced dimensions of the cerebrum and cerebellum, inversely proportional in severity to the gestational age at which ENU was administered. The degrees of micrencephaly were first evident in 15‐day‐old animals and persisted throughout adulthood.
AB - Wistar rats were injected iv with ethlnitrosourea (ENU) between days 14 and 21 of gestation and the offspring killed 0, 3, 6, 10, 15, 21, and 75 days after birth. The brains obtained from these animals, on macroscopic examination, revealed that ENU produced micrencephaly of variable degrees reflected predominantly in the reduced dimensions of the cerebrum and cerebellum, inversely proportional in severity to the gestational age at which ENU was administered. The degrees of micrencephaly were first evident in 15‐day‐old animals and persisted throughout adulthood.
UR - http://www.scopus.com/inward/record.url?scp=0016232901&partnerID=8YFLogxK
U2 - 10.1002/tera.1420090310
DO - 10.1002/tera.1420090310
M3 - Article
C2 - 4832061
AN - SCOPUS:0016232901
SN - 0040-3709
VL - 9
SP - 305
EP - 315
JO - Teratology
JF - Teratology
IS - 3
ER -