Teratologic effects of ethylnitrosourea on brain development in rats

Michael J. Pfaffenroth, Gopal D. Das, James P. McAllister

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Wistar rats were injected iv with ethlnitrosourea (ENU) between days 14 and 21 of gestation and the offspring killed 0, 3, 6, 10, 15, 21, and 75 days after birth. The brains obtained from these animals, on macroscopic examination, revealed that ENU produced micrencephaly of variable degrees reflected predominantly in the reduced dimensions of the cerebrum and cerebellum, inversely proportional in severity to the gestational age at which ENU was administered. The degrees of micrencephaly were first evident in 15‐day‐old animals and persisted throughout adulthood.

Original languageEnglish
Pages (from-to)305-315
Number of pages11
Issue number3
StatePublished - Jun 1974


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