Tension-Time Integrals and Genetic Cardiomyopathy: The Force Is with You

Research output: Contribution to journalShort surveypeer-review

1 Scopus citations

Abstract

Hundreds of different mutations in genes encoding a few dozen sarcomeric proteins cause two reciprocal human disease phenotypes, hypertrophic or dilated cardiomyopathy. How molecular dysfunction evokes different patterns of cardiac remodeling is unclear. Davis et al. describe a biophysical metric of cardiomyocyte function, the force-time integral, which predicts disease phenotype.

Original languageEnglish
Pages (from-to)1049-1050
Number of pages2
JournalCell
Volume165
Issue number5
DOIs
StatePublished - May 19 2016

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