Tension-Time Integrals and Genetic Cardiomyopathy: The Force Is with You

Gerald W. Dorn

doi:10.1016/j.cell.2016.04.036

Tension-Time Integrals and Genetic Cardiomyopathy: The Force Is with You

Gerald W. Dorn

Research output: Contribution to journal › Short survey › peer-review

3 Scopus citations

Abstract

Hundreds of different mutations in genes encoding a few dozen sarcomeric proteins cause two reciprocal human disease phenotypes, hypertrophic or dilated cardiomyopathy. How molecular dysfunction evokes different patterns of cardiac remodeling is unclear. Davis et al. describe a biophysical metric of cardiomyocyte function, the force-time integral, which predicts disease phenotype.

Original language	English
Pages (from-to)	1049-1050
Number of pages	2
Journal	Cell
Volume	165
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2016.04.036
State	Published - May 19 2016

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title = "Tension-Time Integrals and Genetic Cardiomyopathy: The Force Is with You",

abstract = "Hundreds of different mutations in genes encoding a few dozen sarcomeric proteins cause two reciprocal human disease phenotypes, hypertrophic or dilated cardiomyopathy. How molecular dysfunction evokes different patterns of cardiac remodeling is unclear. Davis et al. describe a biophysical metric of cardiomyocyte function, the force-time integral, which predicts disease phenotype.",

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AB - Hundreds of different mutations in genes encoding a few dozen sarcomeric proteins cause two reciprocal human disease phenotypes, hypertrophic or dilated cardiomyopathy. How molecular dysfunction evokes different patterns of cardiac remodeling is unclear. Davis et al. describe a biophysical metric of cardiomyocyte function, the force-time integral, which predicts disease phenotype.

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VL - 165

SP - 1049

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JO - Cell

JF - Cell

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Tension-Time Integrals and Genetic Cardiomyopathy: The Force Is with You

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